LMTK3 Antibody (I-17): sc-100418

LMTK3 Antibody (I-17) is a mouse monoclonal IgG1 kappa light chain antibody that detects LMTK3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-LMTK3 antibody (I-17) is available as a non-conjugated format. LMTK3, or lemur tyrosine kinase 3, is a significant protein consisting of 1,460 amino acids and featuring a single protein kinase domain, which places LMTK3 among the members of the protein kinase superfamily. LMTK3 plays a crucial role in cellular signaling pathways, particularly in the phosphorylation of target proteins, which is essential for regulating various cellular processes such as cell division, differentiation, and DNA repair. The phosphorylation events mediated by LMTK3 are vital for maintaining cellular homeostasis and responding to external stimuli. Notably, LMTK3 is expressed at low levels in the brain and testis, where LMTK3 contributes to the modulation of protein functions through ATP-dependent phosphorylation. Understanding LMTK3 function and regulatory mechanisms is important for elucidating LMTK3′s role in health and disease, particularly in contexts such as cancer and neurodegenerative disorders.

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LMTK3 Antibody (I-17) References:

1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.  |  Nagase, T., et al. 2001. DNA Res. 8: 179-87. PMID: 11572484
2. Analysis of tissue-specific differentially methylated regions (TDMs) in humans.  |  Kitamura, E., et al. 2007. Genomics. 89: 326-37. PMID: 17188838
3. Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members.  |  Hanks, SK. and Quinn, AM. 1991. Methods Enzymol. 200: 38-62. PMID: 1956325
4. The kinase LMTK3 promotes invasion in breast cancer through GRB2-mediated induction of integrin β₁.  |  Xu, Y., et al. 2014. Sci Signal. 7: ra58. PMID: 24939894
5. LMTK3 Represses Tumor Suppressor-like Genes through Chromatin Remodeling in Breast Cancer.  |  Xu, Y., et al. 2015. Cell Rep. 12: 837-49. PMID: 26212333
6. LMTK3 escapes tumour suppressor miRNAs via sequestration of DDX5.  |  Jacob, J., et al. 2016. Cancer Lett. 372: 137-46. PMID: 26739063
7. LMTK3 confers chemo-resistance in breast cancer.  |  Stebbing, J., et al. 2018. Oncogene. 37: 3113-3130. PMID: 29540829
8. LMTK3 promotes tumorigenesis in bladder cancer via the ERK/MAPK pathway.  |  Jiang, T., et al. 2020. FEBS Open Bio. 10: 2107-2121. PMID: 32865871
9. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.  |  Hanks, SK., et al. 1988. Science. 241: 42-52. PMID: 3291115
10. Sequence patterns in protein kinases.  |  Bairoch, A. and Claverie, JM. 1988. Nature. 331: 22. PMID: 3340146
11. LMTK3 inhibition affects microtubule stability.  |  Cilibrasi, C., et al. 2021. Mol Cancer. 20: 53. PMID: 33731143
12. The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor.  |  Agnarelli, A., et al. 2023. Int J Mol Sci. 24: PMID: 36614307

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LMTK3 Antibody (I-17) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-LMTK3 Antibody (I-17) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LMTK3 Antibody (I-17) Specifications

Alternate Product Name: LMTK3

Product Clone Name: I-17

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1151-1250

Epitope Target: LMTK3

Epitope Species: human

Product Reactivity/Detection: LMTK3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for LMTK3 Antibody (I-17): N/A