Date published: 2026-5-22

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Lithium acetoacetate (CAS 3483-11-2)

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Alternate Names:
LithoTab acetoacetate; Lithium 3-Oxobutyrate; Acetoacetic acid lithium salt
Application:
Lithium acetoacetate is a building block and ketone indicator
CAS Number:
3483-11-2
Molecular Weight:
108.02
Molecular Formula:
C4H5LiO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Lithium acetoacetate functions as a reagent in organic synthesis. It acts as a source of the acetoacetate anion, which can undergo condensation reactions with aldehydes and ketones to form β-keto esters and β-diketones. Lithium Acetoacetate can also participate in the Claisen condensation reaction, leading to the formation of β-keto esters. Lithium acetoacetate can be used as a catalyst in the Knoevenagel condensation, facilitating the formation of α, β-unsaturated carbonyl compounds. Its mechanism of action involves the deprotonation of the acetoacetate group, allowing it to act as a nucleophile in various organic reactions. Lithium Acetoacetate′s role in organic synthesis involves its ability to participate in key carbon-carbon bond-forming reactions, contributing to the production of diverse organic compounds.


Lithium acetoacetate (CAS 3483-11-2) References

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  2. Preparation of crystalline lithium acetoacetate.  |  HALL, LM. 1962. Anal Biochem. 3: 75-80. PMID: 13903884
  3. Effects of ketones, acetate, butyrate, and glucose on bovine lymphocyte proliferation.  |  Franklin, ST., et al. 1991. J Dairy Sci. 74: 2507-14. PMID: 1918530
  4. Tyrosine-derived 4-hydroxyphenylpyruvate reacts with ketone test fields of 3 commercially available urine dipsticks.  |  Cartwright, J. and Green, RM. 2010. Vet Clin Pathol. 39: 354-7. PMID: 20487432
  5. Neuroprotection by acetoacetate and β-hydroxybutyrate against NMDA-induced RGC damage in rat--possible involvement of kynurenic acid.  |  Thaler, S., et al. 2010. Graefes Arch Clin Exp Ophthalmol. 248: 1729-35. PMID: 20532550
  6. Ketone bodies promote a rapid rise in glutamate efflux from the isolated perfused rat liver without altering the rate of glutamine production.  |  Almond, MK., et al. 1995. Amino Acids. 9: 141-6. PMID: 24178814
  7. Identification of novel sesquiterpene synthase genes that mediate the biosynthesis of valerianol, which was an unknown ingredient of tea.  |  Hattan, JI., et al. 2018. Sci Rep. 8: 12474. PMID: 30127518
  8. Lithium and Not Acetoacetate Influences the Growth of Cells Treated with Lithium Acetoacetate.  |  Vidali, S., et al. 2019. Int J Mol Sci. 20: PMID: 31242642
  9. In vitro ketone-supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle.  |  Petrick, HL., et al. 2020. J Physiol. 598: 4869-4885. PMID: 32735362
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Lithium acetoacetate, 10 mg

sc-215253
10 mg
$42.00

Lithium acetoacetate, 250 mg

sc-215253A
250 mg
$97.00

Lithium acetoacetate, 1 g

sc-215253B
1 g
$124.00

Lithium acetoacetate, 5 g

sc-215253C
5 g
$379.00