Liranaftate (CAS 88678-31-3)

Liranaftate is a synthetic chemical compound categorized under the thiocarbamate class, renowned for its antifungal properties, specifically targeting a broad spectrum of dermatophytes and yeast-like fungi. The mechanism of action of liranaftate involves the inhibition of squalene epoxidase, an enzyme crucial for ergosterol synthesis, which is an essential component of the fungal cell membrane. By inhibiting this enzyme, liranaftate disrupts the cell membrane′s integrity, leading to the accumulation of toxic intermediates such as squalene, thus hindering fungal cell growth and proliferation. In research contexts, liranaftate has been extensively utilized to study the biochemical pathways involved in fungal ergosterol biosynthesis. This research has been instrumental in understanding the adaptive mechanisms fungi employ to resist antifungal agents and in exploring the molecular basis of enzyme inhibition by thiocarbamates. Furthermore, the effectiveness of liranaftate in inhibiting specific fungal enzymes has provided insights into potential targets for new antifungal agents, contributing significantly to the fields of microbiology and biochemistry. Through such studies, liranaftate not only aids in advancing our knowledge of fungal physiology and pathology but also enhances our understanding of the complex interactions within fungal cells that can be manipulated for various non-therapeutic applications in science.