Molecular structure of Lipoxin A4, 15-epi, CAS Number: 171030-11-8
Lipoxin A4, 15-epi (CAS 171030-11-8)
Alternate Names:
AT-Lipoxin A4; 15-epi Lipoxin A4; 15(R)-LXA4
Application:
Lipoxin A4, 15-epi is a LXA4 analog that is more potent and metabolically stable than LXA4 shown to block IL-8 release
CAS Number:
171030-11-8
Purity:
>98%
Molecular Weight:
352.5
Molecular Formula:
C20H32O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lipoxin A4, 15-epi is an epimeric lipoxin A4 (catalog number sc-201060) analog that is more potent and metabolically stable than LXA4. Has been shown to exhibit anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte tafficking/infiltration. Lipoxin A4, 15-epi blocks TNF-a-induced IL-8 release in human enterocyte. It is also an important modulator of the many pharmacological actions caused by aspirin.
Lipoxin A4, 15-epi (CAS 171030-11-8) References
- Hepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A(4). | Titos, E., et al. 1999. Am J Physiol. 277: C870-7. PMID: 10564079
- Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 modulate adhesion molecule expression on human leukocytes in whole blood and inhibit neutrophil-endothelial cell adhesion. | Filep, JG., et al. 2002. Adv Exp Med Biol. 507: 223-8. PMID: 12664589
- A magic bullet for mucosal protection..and aspirin is the trigger! | Wallace, JL. and Fiorucci, S. 2003. Trends Pharmacol Sci. 24: 323-6. PMID: 12871661
- 15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury. | El Kebir, D., et al. 2009. Am J Respir Crit Care Med. 180: 311-9. PMID: 19483113
- 15-epi-lipoxin A4 reduces the mortality of prematurely born pups in a mouse model of infection-induced preterm birth. | Rinaldi, SF., et al. 2015. Mol Hum Reprod. 21: 359-68. PMID: 25567326
- Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. | Clària, J. and Serhan, CN. 1995. Proc Natl Acad Sci U S A. 92: 9475-9. PMID: 7568157
- Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils. | Serhan, CN., et al. 1995. Biochemistry. 34: 14609-15. PMID: 7578068
- Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation. | Clària, J., et al. 1996. Mol Med. 2: 583-96. PMID: 8898374
- Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. | Maddox, JF., et al. 1997. J Biol Chem. 272: 6972-8. PMID: 9054386
- Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release. | Gronert, K., et al. 1998. J Exp Med. 187: 1285-94. PMID: 9547339
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lipoxin A4, 15-epi , 25 µg | sc-202695 | 25 µg | $248.00 |