Molecular structure of Lipoprotein Lipase Activator, CAS Number: 133208-93-2
Lipoprotein Lipase Activator (CAS 133208-93-2)
Alternate Names:
NO-1886; Diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate; Ibrolipim
Application:
Lipoprotein Lipase Activator is an inducer of lipoprotein lipase mRNA
CAS Number:
133208-93-2
Purity:
≥95%
Molecular Weight:
451.25
Molecular Formula:
C19H20BrN2O4P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A cell-permeable benzylphosphonate derivative that selectively induces lipoprotein lipase (LPL) mRNA and protein levels, but does not exhibit PPARa or PPARg agonistic activities. Lowers serum lipid levels and plasma triglycerides with concomitant elevation in high-density lipoprotein cholesterol (HDL-C) in animal models. Induces fatty acid oxidation related enzymes, lowers free fatty acids (FFA), and minimizes fat accumulation. Also reported to suppress the plasma levels of TNF-a and COX-2 and displays anti-tumor properties.
Lipoprotein Lipase Activator (CAS 133208-93-2) References
Niho, N., et al. 2005. Proc, Natl. Acad. Sci. USA 102, 2970. Yin, W., et al. 2004. Pharmacol. Res. 49, 199. Doi, M., et al. 2003. Metabolism 52, 1547. Kusunoki, M., et al. 2000. Diabetologia 43, 875. Tsutsmi, K., et al. 1993. J. Clin. Invest. 92, 411.Activator of:
Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lipoprotein Lipase Activator, 5 mg | sc-204059 | 5 mg | $141.00 |