Molecular structure of Linvanil, CAS Number: 104899-01-6
Linvanil (CAS 104899-01-6)
Application:
Linvanil is a TRPV1 ligand
CAS Number:
104899-01-6
Molecular Weight:
413.60
Molecular Formula:
C26H39NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Linvanil is a TRPV1 ligand with low affinity to CB1 receptor (Ki = 3.4 μM). Linvanil inhibits anandamide uptake (IC50 = 8.0 μM).
Linvanil (CAS 104899-01-6) References
- Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors. | Melck, D., et al. 1999. Biochem Biophys Res Commun. 262: 275-84. PMID: 10448105
- Anandamide uptake by human endothelial cells and its regulation by nitric oxide. | Maccarrone, M., et al. 2000. J Biol Chem. 275: 13484-92. PMID: 10788462
- Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. | De Petrocellis, L., et al. 2000. FEBS Lett. 483: 52-6. PMID: 11033355
- The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors. | Bisogno, T., et al. 2001. Eur J Biochem. 268: 1982-9. PMID: 11277920
- Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues. | Di Marzo, V., et al. 2001. Eur J Pharmacol. 420: 123-31. PMID: 11408034
- Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors. | Brooks, JW., et al. 2002. Eur J Pharmacol. 439: 83-92. PMID: 11937096
- Effects of the vanilloid agonist olvanil and antagonist capsazepine on rat behaviors. | Kasckow, JW., et al. 2004. Prog Neuropsychopharmacol Biol Psychiatry. 28: 291-5. PMID: 14751425
- 2-Arachidonoylglycerol (2-AG) membrane transport: history and outlook. | Hermann, A., et al. 2006. AAPS J. 8: E409-12. PMID: 16808043
- Reactive intermediates produced from the metabolism of the vanilloid ring of capsaicinoids by p450 enzymes. | Reilly, CA., et al. 2013. Chem Res Toxicol. 26: 55-66. PMID: 23088752
- Formation of long-chain N-vanillyl-acylamides from plant oils. | Kobata, K., et al. 2014. Biosci Biotechnol Biochem. 78: 1242-5. PMID: 25229865
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Linvanil, 5 mg | sc-205951 | 5 mg | $299.00 |