Molecular structure of Linopirdine dihydrochloride, CAS Number: 113168-57-3
Linopirdine dihydrochloride (CAS 113168-57-3)
Alternate Names:
DuP 996
Application:
Linopirdine dihydrochloride is a KCNQ (Kv7) blocker
CAS Number:
113168-57-3
Molecular Weight:
464.39
Molecular Formula:
C26H21N3O•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Linopirdine dihydrochloride acts as a blocker of Kv7 voltage-gated potassium channels (KCNQ); blocks KCNQ2+3/M-currents (IC50 = 4-7 μM) and KCNQ1 homomeric channels (IC50 = 8.9 μM). DuP 996 increases hippocampal ACh release and is a cognitive enhancer following oral administration.
Linopirdine dihydrochloride (CAS 113168-57-3) References
- Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension. | Morecroft, I., et al. 2009. Br J Pharmacol. 157: 1241-9. PMID: 19508393
- Vasorelaxation by hydrogen sulphide involves activation of Kv7 potassium channels. | Martelli, A., et al. 2013. Pharmacol Res. 70: 27-34. PMID: 23287425
- Role of Kv7 channels in responses of the pulmonary circulation to hypoxia. | Sedivy, V., et al. 2015. Am J Physiol Lung Cell Mol Physiol. 308: L48-57. PMID: 25361569
- The Role of KV7.3 in Regulating Osteoblast Maturation and Mineralization. | Yang, JE., et al. 2016. Int J Mol Sci. 17: 407. PMID: 26999128
- Electrophysiological characterization of the M-current in rat hypoglossal motoneurons. | Ghezzi, F., et al. 2017. Neuroscience. 340: 62-75. PMID: 27984184
- Cholinergic Modulation of Membrane Properties of Calyx Terminals in the Vestibular Periphery. | Ramakrishna, Y., et al. 2021. Neuroscience. 452: 98-110. PMID: 33197502
- Asenapine, an atypical antipsychotic, blocks voltage-gated potassium channels in rabbit coronary artery smooth muscle cells. | Seo, MS., et al. 2022. Eur J Pharmacol. 934: 175318. PMID: 36209925
- Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. | Zaczek, R., et al. 1998. J Pharmacol Exp Ther. 285: 724-30. PMID: 9580619
- Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons. | Schnee, ME. and Brown, BS. 1998. J Pharmacol Exp Ther. 286: 709-17. PMID: 9694925
Inhibitor of:
KCNA10, and KV4.3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Linopirdine dihydrochloride, 10 mg | sc-204058 | 10 mg | $165.00 | |||
Linopirdine dihydrochloride, 50 mg | sc-204058A | 50 mg | $700.00 |