Date published: 2025-11-29

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Linoleic acid sodium salt (CAS 822-17-3)

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Alternate Names:
Sodium linoleate; cis-9,cis-12-Octadecadienoic acid sodium salt
Application:
Linoleic acid sodium salt is a precursor to arachidonic acid and other prostaglandins
CAS Number:
822-17-3
Purity:
≥98%
Molecular Weight:
302.43
Molecular Formula:
C18H31O2•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Linoleic acid sodium salt is a compound used in various research disciplines, including nutrition science, biochemistry, and cell biology. In nutrition research, it serves as a model to study the role of fatty acids in the human diet, particularly as linoleic acid is an essential omega-6 fatty acid. Biochemists investigate the incorporation of linoleic acid sodium salt into cell membranes and its effect on membrane fluidity and function. Moreover, this compound is instrumental in examining the enzymatic pathways of lipid metabolism, as well as the production of eicosanoids, which are signaling molecules that play a key role in inflammation and immunity. In cell culture studies, linoleic acid sodium salt is added to media to assess its influence on cell growth and differentiation. Additionally, it is used in the development of lipid-based chemical delivery systems, where the salt form enhances the solubility of lipophilic compounds.


Linoleic acid sodium salt (CAS 822-17-3) References

  1. Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements.  |  Yoshikawa, T., et al. 2002. J Biol Chem. 277: 1705-11. PMID: 11694526
  2. Biological evaluation of several coumarin derivatives designed as possible anti-inflammatory/antioxidant agents.  |  Kontogiorgis, C. and Hadjipavlou-Litina, D. 2003. J Enzyme Inhib Med Chem. 18: 63-9. PMID: 12751823
  3. Malassezia globosa tends to grow actively in summer conditions more than other cutaneous Malassezia species.  |  Akaza, N., et al. 2012. J Dermatol. 39: 613-6. PMID: 22229642
  4. Minor iridoids from Scutellaria albida ssp. albida. Inhibitory potencies on lipoxygenase, linoleic acid lipid peroxidation and antioxidant activity of iridoids from Scutellaria sp.  |  Gousiadou, C., et al. 2013. J Enzyme Inhib Med Chem. 28: 704-10. PMID: 22630074
  5. Study of the antioxidant activity of Thymus sibthorpii Bentham (Lamiaceae).  |  Kontogiorgis, C., et al. 2016. J Enzyme Inhib Med Chem. 31: 154-159. PMID: 27612190
  6. Different effectiveness of two pastas supplemented with either lipophilic or hydrophilic/phenolic antioxidants in affecting serum as evaluated by the novel Antioxidant/Oxidant Balance approach.  |  Laus, MN., et al. 2017. Food Chem. 221: 278-288. PMID: 27979203
  7. PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH.  |  Kukreja, RC., et al. 1986. Circ Res. 59: 612-9. PMID: 3028671
  8. Control of endothelial leukocyte adhesion molecules by fatty acids.  |  De Caterina, R. and Libby, P. 1996. Lipids. 31 Suppl: S57-63. PMID: 8729095
  9. Anorectic activity of prostaglandin precursors.  |  Doggett, NS. and Jawaharlal, K. 1977. Br J Pharmacol. 60: 417-23. PMID: 890209
  10. Detection of free radicals produced from the reaction of cytochrome P-450 with linoleic acid hydroperoxide.  |  Rota, C., et al. 1997. Biochem J. 328 (Pt 2): 565-71. PMID: 9371716
  11. Linoleic acid induces relaxation and hyperpolarization of the pig coronary artery.  |  Pomposiello, SI., et al. 1998. Hypertension. 31: 615-20. PMID: 9461230
  12. Effects of fatty acids on serum binding between furosemide and valproic acid.  |  Takamura, N., et al. 1998. Biol Pharm Bull. 21: 174-6. PMID: 9514615
  13. Growth on urea can trigger death and peroxidation of the cyanobacterium Synechococcus sp. strain PCC 7002.  |  Sakamoto, T., et al. 1998. Appl Environ Microbiol. 64: 2361-6. PMID: 9647800

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Linoleic acid sodium salt, 100 mg

sc-215247
100 mg
$59.00

Linoleic acid sodium salt, 500 mg

sc-215247A
500 mg
$85.00

I am looking for a suitable cell culture medium containing Linoleic acid sodium salt (CAS 822-17-3) for use as a food additive. Could you please confirm if this meets the requirements?

Asked by: ARBK
Thank you for your question. Our products are for research use only, can't be used as food additive.
Answered by: Technical Service SH
Date published: 2024-05-08
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Rated 4 out of 5 by from fast shippingI bought this product recently. I bought it to make substrate for a lipoxygenase assay. The product came as powder/flakes that had two colors, white and beige. The assays were reproducible so I guess the product was good.
Date published: 2017-08-15
Rated 5 out of 5 by from VaughanVaughan, RA. et al. (PubMed 26404455) reported that a high Linoleic acid diet does not induce inflammation in mouse liver or adipose tissue. -SCBT Publication Review
Date published: 2015-01-03
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Linoleic acid sodium salt is rated 4.5 out of 5 by 2.
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