Date published: 2025-12-5

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Linoleamide (CAS 3072-13-7)

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Alternate Names:
Linoleic acid amide; 9,12-Octadecadienamide
Application:
Linoleamide is an unsaturated analog of endogenous sleep-inducing lipid
CAS Number:
3072-13-7
Purity:
≥98%
Molecular Weight:
279.46
Molecular Formula:
C18H33NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Linoleamide, a fatty acid amide, is prominent in biochemical research, especially in studies concerning lipid signaling pathways and cellular communication. As an endogenous signaling molecule, it draws significant interest for its role in modulating inflammatory responses and its involvement in the complex network of bioactive lipids. Researchers investigate the mechanisms by which linoleamide impacts cell-to-cell interactions and how it influences intracellular processes. Its function in the context of homeostasis and the regulation of sleep patterns also garners attention, offering a window into the interplay between lipids and physiological functions. Additionally, linoleamide serves as a model compound in lipidomics to better understand the structure-activity relationships of lipid-derived modulators.


Linoleamide (CAS 3072-13-7) References

  1. Linoleamide, a brain lipid that induces sleep, increases cytosolic Ca2+ levels in MDCK renal tubular cells.  |  Huang, JK. and Jan, CR. 2001. Life Sci. 68: 997-1004. PMID: 11212875
  2. The biohydrogenation of linoleamide in vitro and its effects on linoleic acid concentration in duodenal contents of sheep.  |  Jenkins, TC. and Adams, CS. 2002. J Anim Sci. 80: 533-40. PMID: 11881938
  3. Anti-inflammatory effects of fatty acids isolated from Chromolaena odorata.  |  Hanh, TT., et al. 2011. Asian Pac J Trop Med. 4: 760-3. PMID: 22014728
  4. Detection and qualitative analysis of fatty acid amides in the urine of alcoholics using HPLC-QTOF-MS.  |  Dabur, R. and Mittal, A. 2016. Alcohol. 52: 71-78. PMID: 27139240
  5. Identification of novel inhibitors of human SPCA2.  |  Yamamoto, S., et al. 2016. Biochem Biophys Res Commun. 477: 266-70. PMID: 27297103
  6. Inhibitory action of linoleamide and oleamide toward sarco/endoplasmic reticulum Ca2+-ATPase.  |  Yamamoto, S., et al. 2017. Biochim Biophys Acta Gen Subj. 1861: 3399-3405. PMID: 27595606
  7. Maternal plasma metabolic fingerprint indicative for fetal Down syndrome.  |  Parfieniuk, E., et al. 2018. Prenat Diagn. 38: 876-882. PMID: 30094843
  8. N-Palmitoylglycine and other N-acylamides activate the lipid receptor G2A/GPR132.  |  Foster, JR., et al. 2019. Pharmacol Res Perspect. 7: e00542. PMID: 31768260
  9. Serum Metabolic Profiling Analysis of Chronic Gastritis and Gastric Cancer by Untargeted Metabolomics.  |  Yu, L., et al. 2021. Front Oncol. 11: 636917. PMID: 33777793
  10. Untargeted metabolomic study of HepG2 cells under the effect of Fucus vesiculosus aqueous extract.  |  André, R., et al. 2021. Rapid Commun Mass Spectrom. 35: e9197. PMID: 34515383
  11. Neonatal Supplementation of Oleamide During Suckling Promotes Learning Ability and Memory in Adolescent Mice.  |  Tao, R., et al. 2022. J Nutr. 152: 889-898. PMID: 34967906
  12. Bioprospecting of Less-Polar Fractions of Ericaria crinita and Ericaria amentacea: Developmental Toxicity and Antioxidant Activity.  |  Radman, S., et al. 2022. Mar Drugs. 20: PMID: 35049912
  13. Elevated level of lysophosphatidic acid among patients with HNF1B mutations and its role in RCAD syndrome: a multiomic study.  |  Małachowska, B., et al. 2022. Metabolomics. 18: 15. PMID: 35179657
  14. Qualitative and Quantitative Analysis of Six Fatty Acid Amides in 11 Edible Vegetable Oils Using Liquid Chromatography-Mass Spectrometry.  |  Li, Z., et al. 2022. Front Nutr. 9: 857858. PMID: 35419400

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Linoleamide, 10 mg

sc-221852
10 mg
$82.00

Linoleamide, 50 mg

sc-221852A
50 mg
$347.00