LIN-9 Antibody (Mab#6): sc-130572

LIN-9 Antibody (Mab#6) is a mouse monoclonal IgG1 antibody that detects LIN-9 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). LIN-9, also known as TGS, BARA, or TGS1, is a 542 amino acid protein that plays a crucial role in regulating the cell cycle by functioning as a component of the DREAM complex, which is essential for the repression of cell cycle-dependent genes. The DREAM complex is vital for maintaining proper cellular function and preventing uncontrolled cell proliferation, making LIN-9 an important tumor suppressor. LIN-9 interacts with the retinoblastoma protein (Rb), inhibiting DNA synthesis and potentially regulating the expression of genes necessary for the G1/S transition of the cell cycle. The gene encoding LIN-9 is located on human chromosome 1, which encompasses a large portion of the human genome, containing over 3,000 genes. Additionally, LIN-9 exists in three isoforms due to alternative splicing, which may contribute to diverse regulatory functions in different tissues, particularly in the testis and thymus. Anti-LIN-9 antibody (Mab#6) serves as an invaluable tool for researchers studying cell cycle regulation and tumor biology.

The preferred LIN-9 antibody is LIN-9 Antibody (C-10): sc-398234.