Molecular structure of Limaprost, CAS Number: 74397-12-9
Limaprost (CAS 74397-12-9)
Alternate Names:
11α,15S-dihydroxy-17S,20-dimethyl-9-oxo-prosta-2E,13E-dien-1-oic acid
Application:
Limaprost is a PGE1 analog and potent platelet adhesion inhibitor
CAS Number:
74397-12-9
Purity:
≥98%
Molecular Weight:
380.5
Molecular Formula:
C22H36O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
An analog of PGE1 with structural modifications intended to give a prolonged half-life and greater potency. It is orally active in both guinea pigs and rats at doses of 100 µg/kg as an inhibitor of ADP and collagen induced platelet aggregation. It is 10-1,000 times more potent than PGE1 as a platelet adhesive inhibitor, measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 µg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 µg/kg orally in rats.1
Limaprost (CAS 74397-12-9) References
1 Tsuboi, T., Hatano, N., Nakatsuji, K., et al. Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent. Arch Int Pharmacodyn 247 89-102 (1980).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Limaprost, 1 mg | sc-205374 | 1 mg | $138.00 | |||
Limaprost, 5 mg | sc-205374A | 5 mg | $497.00 |