Date published: 2026-4-21

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Lewis-Y tetrasaccharide (CAS 82993-43-9)

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Application:
Lewis-Y tetrasaccharide is a determinant for Lewis-Y blood group
CAS Number:
82993-43-9
Molecular Weight:
675.63
Molecular Formula:
C26H45NO19
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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The Lewis-Y tetrasaccharide, a carbohydrate molecule consisting of four sugar units. Its presence on the surface of cancer cells is of particular interest due to its involvement in cell adhesion and metastasis. Comprehending the mechanism of action of the Lewis-Y tetrasaccharide proves to be a complex task, with numerous facets yet to be fully understood. However, it is hypothesized that the molecule interacts with distinct receptors present on the surface of cancer cells, thereby impeding their growth and preventing metastasis to other parts of the body.


Lewis-Y tetrasaccharide (CAS 82993-43-9) References

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  2. The immunogenicity of the tumor-associated antigen Lewis(y) may be suppressed by a bifunctional cross-linker required for coupling to a carrier protein.  |  Buskas, T., et al. 2004. Chemistry. 10: 3517-24. PMID: 15252797
  3. NMR study on the hydroxy protons of the Lewis X and Lewis Y oligosaccharides.  |  Bekiroglu, S., et al. 2004. Carbohydr Res. 339: 2465-8. PMID: 15388363
  4. Two distinct alpha-L-fucosidases from Bifidobacterium bifidum are essential for the utilization of fucosylated milk oligosaccharides and glycoconjugates.  |  Ashida, H., et al. 2009. Glycobiology. 19: 1010-7. PMID: 19520709
  5. Crystallography of a Lewis-binding norovirus, elucidation of strain-specificity to the polymorphic human histo-blood group antigens.  |  Chen, Y., et al. 2011. PLoS Pathog. 7: e1002152. PMID: 21811409
  6. Towards a structural basis for the relationship between blood group and the severity of El Tor cholera.  |  Mandal, PK., et al. 2012. Angew Chem Int Ed Engl. 51: 5143-6. PMID: 22488789
  7. Antibody-Carbohydrate Recognition from Docked Ensembles Using the AutoMap Procedure.  |  Dingjan, T., et al. 2015. Methods Mol Biol. 1331: 41-55. PMID: 26169734
  8. Attachment of norovirus to histo blood group antigens: a cooperative multistep process.  |  Mallagaray, A., et al. 2015. Angew Chem Int Ed Engl. 54: 12014-9. PMID: 26329854
  9. Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides.  |  Weichert, S., et al. 2016. J Virol. 90: 4843-4848. PMID: 26889023
  10. Lewis fucose is a key moiety for the recognition of histo-blood group antigens by GI.9 norovirus, as revealed by structural analysis.  |  Kimura-Someya, T., et al. 2022. FEBS Open Bio. 12: 560-570. PMID: 35038379
  11. Purification and characterization of a hemocyanin with lectin-like activity isolated from the hemolymph of speckled shrimp, Metapenaeusmonoceros.  |  Dilna, C., et al. 2023. Biochimie. 206: 36-48. PMID: 36216224
  12. Molecular recognition of the Lewis Y antigen by monoclonal antibodies.  |  Blaszczyk-Thurin, M., et al. 1996. Protein Eng. 9: 447-59. PMID: 8795045
  13. Molecular recognition of a peptide mimic of the Lewis Y antigen by an anti-Lewis Y antibody.  |  Murali, R. and Kieber-Emmons, T. 1997. J Mol Recognit. 10: 269-76. PMID: 9770651

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Lewis-Y tetrasaccharide, 1 mg

sc-300917
1 mg
$336.00