Date published: 2026-4-28

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Levothyroxine sodium (CAS 25416-65-3)

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Alternate Names:
3,3′,5,5′-Tetraiodo-L-thyronine monosodium salt; L-Thyroxin monosodium salt; Sodium O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine
CAS Number:
25416-65-3
Molecular Weight:
798.85
Molecular Formula:
C15H10I4NO4•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Levothyroxine sodium is a derivative of the thyroid hormone thyroxine (T4). Levothyroxine sodium presents as a white, crystalline powder, devoid of odor and possessing a mildly bitter taste. Notably, it exhibits solubility in both water and alcohol. The application of levothyroxine sodium encompasses various objectives. It serves for investigating the impact of thyroid hormones, as well as examining the effects of hypothyroidism. Levothyroxine sodium acts as the active form of thyroxine, binding to specific receptors situated on the surface of cells. This interaction triggers the production of proteins and enzymes involved in metabolic processes. Levothyroxine sodiumheightens the metabolic rate and promotes energy production.


Levothyroxine sodium (CAS 25416-65-3) References

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  2. Current methodology to assess bioequivalence of levothyroxine sodium products is inadequate.  |  Blakesley, VA. 2005. AAPS J. 7: E42-6. PMID: 16146348
  3. Pharmaceutical studies of levothyroxine sodium hydrate suppository provided as a hospital preparation.  |  Hamada, Y., et al. 2015. Biol Pharm Bull. 38: 625-8. PMID: 25832643
  4. MANAGEMENT OF ENDOCRINE DISEASE: Pitfalls on the replacement therapy for primary and central hypothyroidism in adults.  |  de Carvalho, GA., et al. 2018. Eur J Endocrinol. 178: R231-R244. PMID: 29490937
  5. Blister-packed levothyroxine sodium or bottle-packed levothyroxine sodium.  |  Gupta, D., et al. 2018. J Basic Clin Physiol Pharmacol. 29: 309-311. PMID: 29949511
  6. Pharmacokinetics and Comparative Bioavailability of a Levothyroxine Sodium Oral Solution and Soft Capsule.  |  Tanguay, M., et al. 2019. Clin Pharmacol Drug Dev. 8: 521-528. PMID: 30153382
  7. Liver dysfunction induced by Levothyroxine Sodium Tablets (Euthyrox®) in a hypothyroid patient with Hashimoto's thyroiditis: case report and literature review.  |  Yu, H., et al. 2019. Endocr J. 66: 769-775. PMID: 31217393
  8. Partial Dehydration of Levothyroxine Sodium Pentahydrate in a Drug Product Environment: Structural Insights into Stability.  |  Kaur, N., et al. 2020. Mol Pharm. 17: 3915-3929. PMID: 32960611
  9. Levothyroxine Therapy in Gastric Malabsorptive Disorders.  |  Virili, C., et al. 2020. Front Endocrinol (Lausanne). 11: 621616. PMID: 33584549
  10. Investigating the Influence of Excipients on the Stability of Levothyroxine Sodium Pentahydrate.  |  Kaur, N. and Suryanarayanan, R. 2021. Mol Pharm. 18: 2683-2693. PMID: 34061524
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  12. Association Between Generic-to-Generic Levothyroxine Switching and Thyrotropin Levels Among US Adults.  |  Brito, JP., et al. 2022. JAMA Intern Med. 182: 418-425. PMID: 35226058
  13. Effect of Levothyroxine Sodium Tablets on Pregnancy Outcome and Offspring Development Quotient of SCH during Pregnancy.  |  Qian, X., et al. 2022. J Healthc Eng. 2022: 9001881. PMID: 35388329
  14. Systematic review and meta-analysis of the efficacy and pregnancy outcomes of levothyroxine sodium tablet administration in pregnant women complicated with hypothyroidism.  |  Geng, X., et al. 2022. Ann Palliat Med. 11: 1441-1452. PMID: 35523752
  15. Levothyroxine Sodium - Thyroid Hormone Replacement Therapy for Hypothyroidism: A Review of Patent Literature.  |  Upadhyay, U., et al. 2023. Recent Pat Biotechnol. 17: 245-256. PMID: 36515027

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Levothyroxine sodium, 25 mg

sc-235497
25 mg
$317.00