Molecular structure of Levonorgestrel, CAS Number: 797-63-7
Levonorgestrel (CAS 797-63-7)
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Alternate Names:
Norplant
Application:
Levonorgestrel is a synthetic progestin that binds to progesterone and androgen receptors
CAS Number:
797-63-7
Molecular Weight:
312.45
Molecular Formula:
C21H28O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Levonorgestrel is a synthetic progestin that binds to progesterone and androgen receptors but not the estrogen receptor. Induces apoptosis in ovarian epithelium cells. Levonorgestrel functions by attaching itself to progesterone receptors within the body, thereby obstructing the activities of other hormones. Furthermore, it exhibits anti-estrogenic properties, enabling it to hinder the effects of estrogen. Additionally, it possesses anti-androgenic characteristics, enabling it to impede the actions of androgens.
Levonorgestrel (CAS 797-63-7) References
- Several synthetic progestins with different potencies adversely affect reproduction of fish. | Runnalls, TJ., et al. 2013. Environ Sci Technol. 47: 2077-84. PMID: 23360115
- The progestin levonorgestrel disrupts gonadotropin expression and sex steroid levels in pubertal roach (Rutilus rutilus). | Kroupova, HK., et al. 2014. Aquat Toxicol. 154: 154-62. PMID: 24893273
- Mixture effects of levonorgestrel and ethinylestradiol: estrogenic biomarkers and hormone receptor mRNA expression during sexual programming. | Säfholm, M., et al. 2015. Aquat Toxicol. 161: 146-53. PMID: 25703176
- From single chemicals to mixtures--reproductive effects of levonorgestrel and ethinylestradiol on the fathead minnow. | Runnalls, TJ., et al. 2015. Aquat Toxicol. 169: 152-67. PMID: 26551686
- Aqueous exposure to the progestin, levonorgestrel, alters anal fin development and reproductive behavior in the eastern mosquitofish (Gambusia holbrooki). | Frankel, TE., et al. 2016. Gen Comp Endocrinol. 234: 161-9. PMID: 26795917
- Reliability of the AR-CALUX®In Vitro Method Used to Detect Chemicals with (Anti)Androgen Activity: Results of an International Ring Trial. | Milcamps, A., et al. 2021. Toxicol Sci. 184: 170-182. PMID: 34165557
- Levonorgestrel causes feminization and dose-dependent masculinization in medaka fish (Oryzias latipes): Endocrine-disruption activity and its correlation with sex reversal. | Watanabe, A., et al. 2023. Sci Total Environ. 876: 162740. PMID: 36921849
Inhibitor of:
BPY2, Oviductin, Progesterone, STELLA, and ZP2.Activator of:
mPRγ, PIBF, and PR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Levonorgestrel, 100 mg | sc-205731 | 100 mg | $43.00 | |||
Levonorgestrel, 500 mg | sc-205731A | 500 mg | $194.00 |