Date published: 2025-12-7

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Levomefolic Acid-13C,d3 (CAS 31690-09-2 (unlabeled))

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Alternate Names:
N-[4-[[[(6S)-2-Amino-3,4,5,6,7,8-hexahydro-5-(methyl-13C,d3)-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-L-glutamic Acid; (6S)-5-(Methyl-13C,d3)tetrahydrofolic Acid; 5-Methyl-(6S)-tetrahydrofolic Acid-13C,d3
CAS Number:
31690-09-2 (unlabeled)
Molecular Weight:
463.47
Molecular Formula:
C19(13C)H22D3N7O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Levomefolic acid-13C,d3 (LMA-13C,d3) is a synthetic variant of 5-methyltetrahydrofolate (5-MTHF), the naturally occurring form of folate. Folate, an indispensable vitamin, plays a vital role in numerous biochemical processes and physiological functions. Extensive laboratory research has delved into Levomefolic acid-13C,d3, revealing a broad spectrum of advantages. Its application spans various scientific research domains, encompassing investigations into folate metabolism, gene expression, cell signaling, and drug metabolism. Moreover, it has been employed to explore the consequences of folate deficiency and examine the association between folate and diseases like cancer. While the exact mechanism of action for Levomefolic acid-13C,d3 remains incompletely elucidated, it is postulated to function by providing a source of active 5-methyltetrahydrofolate (5-MTHF) within the body. 5-MTHF is vital for an array of biochemical processes, including DNA and RNA synthesis, as well as amino acid metabolism.


Levomefolic Acid-13C,d3 (CAS 31690-09-2 (unlabeled)) References

  1. Simultaneous quantification of intracellular concentrations of clinically important metabolites of folate-homocysteine cycle by LC-MS/MS.  |  Vidmar Golja, M., et al. 2020. Anal Biochem. 605: 113830. PMID: 32717185
  2. Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate.  |  Vidmar Golja, M., et al. 2020. J Clin Med. 9: PMID: 32887268
  3. Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes.  |  Jie, Z., et al. 2022. Genomics Proteomics Bioinformatics. 20: 304-321. PMID: 34118463
  4. The dihydrofolate reductase 19-bp deletion modifies the beneficial effect of B-vitamin therapy in mild cognitive impairment: pooled study of two randomized placebo-controlled trials.  |  Wu, Y., et al. 2022. Hum Mol Genet. 31: 1151-1158. PMID: 34788822
  5. A transomic cohort as a reference point for promoting a healthy human gut microbiome  |  Jie, Z., Liang, S., Ding, Q., Li, F., Tang, S., Wang, D.,.. & Xu, X. 2021. Medicine in Microecology. 8: 100039.
  6. Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites  |  Jie, Z., Liang, S., Ding, Q., Li, F., Sun, X., Lin, Y.,.. & Xu, X. 2021. Medicine in Microecology. 9: 100037.
  7. Dairy consumption and physical fitness tests associated with fecal microbiome in a Chinese cohort  |  Jie, Z., Liang, S., Ding, Q., Li, F., Sun, X., Lin, Y.,.. & Xu, X. 2021. Medicine in Microecology. 9: 100038.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Levomefolic Acid-13C,d3, 1 mg

sc-488863
1 mg
$583.00