Levofloxacin hydrochloride (CAS 177325-13-2)
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Levofloxacin hydrochloride is the hydrochloride salt of Levofloxacin (sc-252953), a fluoroquinolone broad spectrum antibiotic with activity against gram-positive and negative bacteria. Levofloxacin is the active S-(−) isomer of the antibacterial agent ofloxacin (sc-219475) and is significantly more efficacious against bacteria than the R-(+) isomer. Levofloxacin and related fluoroquinolones function by inhibiting Topo II (DNA gyrase) and topoisomerase IV activity and interrupting DNA replication. Levofloxacin binds to the A subunits of DNA gyrase and topoisomerase IV, interfering with their ability to break and reseal DNA strands during replication. This leads to the formation of stable enzyme-DNA cleavage complexes and the accumulation of double-stranded DNA breaks, ultimately resulting in bacterial cell death. Levofloxacin exhibits a bactericidal effect, meaning it actively kills bacteria rather than just inhibiting their growth. It has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria.
Levofloxacin hydrochloride (CAS 177325-13-2) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Levofloxacin hydrochloride, 1 g | sc-202693 | 1 g | $58.00 | |||
Levofloxacin hydrochloride, 5 g | sc-202693A | 5 g | $105.00 |