Molecular structure of Levofloxacin Hemihydrate, CAS Number: 138199-71-0
Levofloxacin Hemihydrate (CAS 138199-71-0)
See product citations (2)
Application:
Levofloxacin Hemihydrate is an antibiotic against gram-negative organisms
CAS Number:
138199-71-0
Purity:
≥99%
Molecular Weight:
370.38
Molecular Formula:
C18H20FN3O4•1/2H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Levofloxacin Hemihydrate is a fluoroquinolone antibiotic against gram-negative organisms. It is also a stereoisomer of ofloxacin (sc-219475). Levofloxacin Hemihydrate works by inhibiting DNA gyrase (or topoisomerase II) and topoisomerase IV. DNA gyrase is essential for bacterial DNA replication, repair, and recombination, while topoisomerase IV plays a key role in partitioning the bacterial chromosomal DNA during bacterial cell division. By inhibiting these enzymes, Levofloxacin Hemihydrate interferes with the bacteria′s ability to replicate and repair its DNA, leading to bacterial death.
Levofloxacin Hemihydrate (CAS 138199-71-0) References
- Validated HPTLC method for simultaneous estimation of levofloxacin hemihydrate and ornidazole in pharmaceutical dosage form. | Chepurwar, SB., et al. 2007. J Chromatogr Sci. 45: 531-6. PMID: 18019564
- Quantitative determination of levofloxacin hemihydrate in bulk and tablets by UV-spectrophotometry and first order derivative methods. | Shirkhedkar, AA. and Surana, SJ. 2009. Pak J Pharm Sci. 22: 301-2. PMID: 19553178
- Antibacterial fluoroquinolone antibiotic-containing fibrous materials from poly(L-lactide-co-D,L-lactide) prepared by electrospinning. | Toncheva, A., et al. 2012. Eur J Pharm Sci. 47: 642-51. PMID: 22910339
- Micellar liquid chromatographic method for the simultaneous determination of Levofloxacin and Ambroxol in combined tablets: Application to biological fluids. | Belal, FF., et al. 2013. Chem Cent J. 7: 162. PMID: 24079576
- Formulation and in vitro evaluation of size expanding gastro-retentive systems of levofloxacin hemihydrate. | El-Zahaby, SA., et al. 2014. Int J Pharm. 464: 10-8. PMID: 24472642
- Preparation and in vitro/in vivo evaluation of antimicrobial ocular in situ gels containing a disappearing preservative for topical treatment of bacterial conjunctivitis. | Saher, O., et al. 2016. Pharm Dev Technol. 21: 600-10. PMID: 25886078
- Formulation and in vitro characterization of poly(dl-lactide-co-glycolide)/Eudragit RLPO or RS30D nanoparticles as an oral carrier of levofloxacin hemihydrate. | Hasan, AA., et al. 2016. Pharm Dev Technol. 21: 655-63. PMID: 25915180
- Effect of repeated oral administration of levofloxacin, enrofloxacin, and meloxicam on antioxidant parameters and lipid peroxidation in rabbits. | Khan, AM., et al. 2017. Hum Exp Toxicol. 36: 42-50. PMID: 26962111
- Effect of a combination of mometasone furoate, levofloxacin, and retinyl palmitate with an in situ gel-forming nasal delivery system on nasal mucosa damage repair in an experimental rabbit model. | Aksoy, F., et al. 2017. Biomed Pharmacother. 96: 603-611. PMID: 29035825
- The use of multicomponent ear drops in the treatment of otitis of various etiologies in animals. | Arisov, MV., et al. 2020. J Adv Vet Anim Res. 7: 115-126. PMID: 32219117
- Effect of xanthan gum-based food thickeners on the dissolution profile of fluoroquinolones oral formulations. | Takahashi, N., et al. 2020. J Pharm Health Care Sci. 6: 25. PMID: 33292643
- Nanoparticles encapsulation of Phoenix dactylifera (date palm) mucilage for colonic drug delivery. | Shahid, M., et al. 2021. Int J Biol Macromol. 191: 861-871. PMID: 34571126
- PK-PD Evaluation of Inhaled Microparticles loaded with Ciprofloxacin-Copper complex in a Rat Model of Chronic Pseudomonas aeruginosa Lung Infection. | Tewes, F., et al. 2023. Int J Pharm X. 5: 100178. PMID: 36970713
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Levofloxacin Hemihydrate, 100 mg | sc-211735 | 100 mg | $195.00 |