Molecular structure of Levocabastine Hydrochloride, CAS Number: 79547-78-7
Levocabastine Hydrochloride (CAS 79547-78-7)
See product citations (4)
Alternate Names:
Levophta; Livostin
Application:
Levocabastine Hydrochloride is a histamine H1 receptor antagonist and anti-allergic agent
CAS Number:
79547-78-7
Purity:
99%
Molecular Weight:
456.98
Molecular Formula:
C26H29FN2O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Levocabastine is known to be a histamine H1 receptor antagonist and anti-allergic agent. This product′s potent and selective H1 receptor antagonist activity has been clinically applied as a topical treatment for seasonal allergic rhinitis. It is also seen as a treatment for allergic conjuctivitis especially in children. A suggested mode of action for levocabastine is its ability to inhibit the release of leukotriene C4 (sc-201046) relieving nasal obstruction for the case of allergic rhinitis. In addition, levocabastine has been observed to be a partial, low affinity neurotensin receptor (NTS2) agonist, but no anti-infammatory properties have been reported.
Levocabastine Hydrochloride (CAS 79547-78-7) References
- The partial agonist properties of levocabastine in neurotensin-induced analgesia. | Dubuc, I., et al. 1999. Eur J Pharmacol. 381: 9-12. PMID: 10528128
- Effects of levocabastine on lipid mediator release from guinea pig lung fragments. | Sugimoto, Y., et al. 1999. Acta Med Okayama. 53: 271-4. PMID: 10631382
- Efficacy, cost-effectiveness, and tolerability of mometasone furoate, levocabastine, and disodium cromoglycate nasal sprays in the treatment of seasonal allergic rhinitis. | Lange, B., et al. 2005. Ann Allergy Asthma Immunol. 95: 272-82. PMID: 16200819
- Efficacy of levocabastine hydrochloride ophthalmic suspension in the conjunctival allergen challenge test in Japanese subjects with seasonal allergic conjunctivitis. | Takamura, E., et al. 2006. Allergol Int. 55: 157-65. PMID: 17075252
- Contribution of alpha4beta1 integrin to the antiallergic effect of levocabastine. | Qasem, AR., et al. 2008. Biochem Pharmacol. 76: 751-62. PMID: 18680729
- The effect of levocabastine hydrochloride on human Tenon's capsule fibroblasts: inhibition of proliferation, suppression of DNA synthesis and induction of apoptosis. | Asaoka, R., et al. 2009. Cutan Ocul Toxicol. 28: 83-9. PMID: 19473114
- Levocabastine nasal spray significantly improves perennial allergic rhinitis: a single-blind placebo-controlled study. | Okubo, K., et al. 2010. Auris Nasus Larynx. 37: 436-42. PMID: 20138720
- The Efficacy of Budesonide, Levocabastine, and Their Combination in Treatment of Vasomotor Rhinitis. | Tan, R., et al. 2023. ORL J Otorhinolaryngol Relat Spec. 85: 321-328. PMID: 37935139
- Selective effect of levocabastine on histamine receptor and histamine release from human leukocytes and guinea pig isolated tissue. | Garrelds, IM., et al. 1996. Ann Allergy Asthma Immunol. 76: 327-34. PMID: 8612114
- Levocabastine. An update of its pharmacology, clinical efficacy and tolerability in the topical treatment of allergic rhinitis and conjunctivitis. | Noble, S. and McTavish, D. 1995. Drugs. 50: 1032-49. PMID: 8612470
- Development and validation of stability-indicating RP-HPLC method for the determination of Levocabastine HCl in bulk drug and in ophthalmic suspensions | Hashem AlAani a, Iman Alashkar b, François Karabet a. 2017. Arabian Journal of Chemistry. 10: S3097-S3107.
Inhibitor of:
Histamine H1 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Levocabastine Hydrochloride, 10 mg | sc-201095 | 10 mg | $192.00 |