Molecular structure of Levcromakalim, CAS Number: 94535-50-9
Levcromakalim (CAS 94535-50-9)
See product citations (2)
Alternate Names:
BRL 38227
Application:
Levcromakalim is an active enantiomer of the prototypical KATP(Kir6) channel opener cromakalim
CAS Number:
94535-50-9
Molecular Weight:
286.33
Molecular Formula:
C16H18N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Levcromakalim is an active enantiomer of the prototypical Kir6 (KATP) channel opener cromakalim. Levcromakalim is thought to work by activating ATP-sensitive potassium channels, which in turn trigger potassium efflux and inhibit calcium influx. Consequently, intracellular calcium levels decrease while intracellular potassium levels increase. These changes ultimately lead to a reduction in the contractile force of the heart muscle, achieving the intended outcome.
Levcromakalim (CAS 94535-50-9) References
- Lipofundin MCT/LCT Inhibits Levcromakalim-Induced Vasodilation by Inhibiting Endothelial Nitric Oxide Release. | Lee, SH., et al. 2020. Int J Mol Sci. 21: PMID: 32143531
- Pharmacological and pharmacokinetic profile of the novel ocular hypotensive prodrug CKLP1 in Dutch-belted pigmented rabbits. | Roy Chowdhury, U., et al. 2020. PLoS One. 15: e0231841. PMID: 32298376
- Latest Insights into the Pathophysiology of Migraine: the ATP-Sensitive Potassium Channels. | Kokoti, L., et al. 2020. Curr Pain Headache Rep. 24: 77. PMID: 33270149
- Opening of ATP sensitive potassium channels causes migraine attacks with aura. | Al-Karagholi, MA., et al. 2021. Brain. 144: 2322-2332. PMID: 33768245
- CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine. | Christensen, SL., et al. 2021. Cephalalgia. 41: 1413-1426. PMID: 34407650
- Brain barriers and their potential role in migraine pathophysiology. | Wiggers, A., et al. 2022. J Headache Pain. 23: 16. PMID: 35081902
- The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target? | Ernstsen, C., et al. 2022. Brain. 145: 2450-2460. PMID: 35136961
- Kv7 Channels in Cyclic-Nucleotide Dependent Relaxation of Rat Intra-Pulmonary Artery. | Al-Chawishly, M., et al. 2022. Biomolecules. 12: PMID: 35327621
- Asymmetric Epoxidation of Olefins with Sodium Percarbonate Catalyzed by Bis-amino-bis-pyridine Manganese Complexes. | Drozd, VA., et al. 2022. Molecules. 27: PMID: 35458734
- Structural identification of vasodilator binding sites on the SUR2 subunit. | Ding, D., et al. 2022. Nat Commun. 13: 2675. PMID: 35562524
- Mechanistic insights on KATP channel regulation from cryo-EM structures. | Driggers, CM. and Shyng, SL. 2023. J Gen Physiol. 155: PMID: 36441147
- PACAP signaling is not involved in GTN- and levcromakalim-induced hypersensitivity in mouse models of migraine. | Guo, S., et al. 2022. J Headache Pain. 23: 155. PMID: 36471250
- Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels. | Bercea, C., et al. 2022. Front Physiol. 13: 1033216. PMID: 36589427
- Prostaglandin-E2 levels over the course of glyceryl trinitrate provoked migraine attacks. | Harder, AVE., et al. 2023. Neurobiol Pain. 13: 100112. PMID: 36636095
- Novel Therapeutic Targets for Migraine. | Nisar, A., et al. 2023. Biomedicines. 11: PMID: 36831105
Activator of:
KIR, KIR6.1, and KIR6.2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Levcromakalim, 10 mg | sc-361230 | 10 mg | $428.00 | |||
Levcromakalim, 50 mg | sc-361230A | 50 mg | $1380.00 |