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Levamisole Hydrochloride (CAS 16595-80-5) - chemical structure image — Molecular structure of Levamisole Hydrochloride, CAS Number: 16595-80-5

Molecular structure of Levamisole Hydrochloride, CAS Number: 16595-80-5

Levamisole Hydrochloride (CAS 16595-80-5)

Name: Levamisole Hydrochloride | CAS 16595-80-5
Brand: SCBT
SKU: sc-205730
Price: 42.0 USD
Availability: InStock

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See product citations (18)

Alternate Names:

Ergamisol; Tramisol; Tramisole; (−)-Tetramisole hydrochloride; Niratic hydrochloride

Application:

Levamisole Hydrochloride is an immunomodulatory agent in human micro-and macro vascular endothelial cells

CAS Number:

16595-80-5

Purity:

≥99%

Molecular Weight:

240.76

Molecular Formula:

C₁₁H₁₂N₂S•HCl

Supplemental Information:

This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data.

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Description

Technical Information

Safety Information

SDS & Certificate of Analysis

Levamisole Hydrochloride is an immunomodulatory agent which selectively induces apoptosis in human micro-and macro vascular endothelial cells. In vitro studies suggest that Levamisole Hydrochloride has been used to cause cytotoxic effects in several types of tumor cell lines by potentiating the anti-proliferative effect of 5-fluorouracil. As a result of the cytotoxic effect of Levamisole Hydrochloride DNA fragmentation, release of cytochrome c into the cytoplasm, and the activation of caspase-3 has been observed in cells. Alternate studies have shown that Levamisole Hydrochloride can be used to inhibit the growth of Toxocara canis. Levamisole Hydrochloride has also been shown to increase T-lymphocyte function and macrophage chemotaxis in rheumatic disorder cells. Levamisole Hydrochloride is an activator of AChR. Levamisole Hydrochloride is an inhibitor of Alkaline Phosphatase.

Levamisole Hydrochloride (CAS 16595-80-5) References

Anti-proliferative effect of levamisole on human myeloma cell lines in vitro. | Ramanadham, M. and Nageshwari, B. 2010. J Immunotoxicol. 7: 327-32. PMID: 20860474
Comparison of the efficacy of crude methanolic extracts of Cassia occidentalis and Euphorbia hirta with levamisole-HCL against gastrointestinal nematodes of economic importance to goat production in Uganda. | Nsereko, G., et al. 2019. Trop Anim Health Prod. 51: 2269-2278. PMID: 31152335
Transcriptomics and coexpression network profiling of the effects of levamisole hydrochloride on Bursaphelenchus xylophilus. | Chen, J., et al. 2022. Pestic Biochem Physiol. 181: 105019. PMID: 35082042
The association between fecal microbiota, age and endoparasitism in adult alpacas. | Bedenice, D., et al. 2022. PLoS One. 17: e0272556. PMID: 36006927
Anthelmintic effect of levamisole hydrochloride or ivermectin on tissue toxocariasis of mice. | Carrillo, M. and Barriga, OO. 1987. Am J Vet Res. 48: 281-3. PMID: 3826867

Inhibitor of:

4933425L06Rik, Akp-3, Alkaline Phosphatase, AMPD2, C20orf54, CANT1, CEMP1, Enpp4, ENPP5, FRP-1, HS3ST4, IAP, Mumps, PTPδ, TNAP, and URO-10.

Activator of:

AChR, ALPPL2, H2-Kk, HLA-D, HLA-DR, HPV16 L1, IFIX, IFN-α10, IFN-α2, IFN-α5, IFN-γ, MHC class I, MHC class II, NTPDase8, PRAMEF15, RAET1G, RT1-EC2, and TAG-72.

Ordering Information

Product Name	Catalog #	UNIT	Price	Qty	FAVORITES
Levamisole Hydrochloride, 5 g	sc-205730	5 g	$42.00
Levamisole Hydrochloride, 10 g	sc-205730A	10 g	$67.00

What is the appearance of the compound?

Asked by: two2igm05

Thank you for your question. The chemical, sc-205730, is provided as a white crystalline powder. if you have any further questions or concerns, please contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.

Answered by: Tech Service 8

Date published: 2017-01-11

Can this chemical be aliquoted and placed in the freezer for later use?

Asked by: two2igm05

Thank you for your question. Levamisole Hydrochloride, sc-205730, can be stored for 6 months at -80°C in DMSO.

Answered by: TechService7

Date published: 2016-12-19

Rated 5 out of 5 by JM from DeracinoisDeracinois, B. et al. (PubMed 26219710) reported that Levamisole-mediated inhibition of tissue nonspecific alkaline phosphatase provokes an increase of the permeability to Lucifer Yellow of the endothelial monolayer. -SCBT Publication Review

Date published: 2015-02-18

Levamisole Hydrochloride is rated 5.0 out of 5 by 1.

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Test	Specification	Results
Appearance	White or almost white crystalline powder	Complies
Purity	> 98.5%	99.7%
Heavy Metals	≤ 5 ppm	Complies
Sulfated Ash	≤ 0.5%	0.01%

Levamisole Hydrochloride (CAS 16595-80-5)

Levamisole Hydrochloride (CAS 16595-80-5) References

SAMPLE Certificate of Analysis (COA)

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Levamisole Hydrochloride, 5 g

Levamisole Hydrochloride, 10 g

What is the appearance of the compound?

Can this chemical be aliquoted and placed in the freezer for later use?