Molecular structure of Leupeptin trifluoroacetate salt, CAS Number: 147385-61-3
Leupeptin trifluoroacetate salt (CAS 147385-61-3)
See product citations (10)
Alternate Names:
Acetyl-Leu-Leu-Arg-al TFA
Application:
Leupeptin trifluoroacetate salt is an inhibitor of plasmin, trypsin, papain and cathepsin B
CAS Number:
147385-61-3
Purity:
≥90%
Molecular Weight:
540.58
Molecular Formula:
C20H38N6O4•C2HF3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Leupeptin trifluoroacetate salt is employed in biochemistry and molecular biology research as an inhibitor of certain proteases, including cysteine, serine, and threonine proteases. Its inhibitory action is often utilized in the preparation of cell lysates to prevent the degradation of proteins, which is for maintaining the integrity of samples in proteomic studies. Researchers also use Leupeptin trifluoroacetate salt in enzyme kinetics experiments to study the activity of proteases and to understand their role in various biological processes. This compound is particularly useful in the field of enzymology for characterizing enzyme mechanisms and determining the specificity of protease inhibitors. Additionally, Leupeptin trifluoroacetate salt is applied in the investigation of intracellular protein turnover and degradation pathways, such as the ubiquitin-proteasome system.
Leupeptin trifluoroacetate salt (CAS 147385-61-3) References
- 125I-alpha-conotoxin MII identifies a novel nicotinic acetylcholine receptor population in mouse brain. | Whiteaker, P., et al. 2000. Mol Pharmacol. 57: 913-25. PMID: 10779374
- Transformation and degradation of the disazo dye Chicago Sky Blue by a purified laccase from Pycnoporus cinnabarinus. | Schliephake, K., et al. 2000. Enzyme Microb Technol. 27: 100-107. PMID: 10862908
- Involvement of the alpha3 subunit in central nicotinic binding populations. | Whiteaker, P., et al. 2002. J Neurosci. 22: 2522-9. PMID: 11923417
- Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors. | Marubio, LM., et al. 2003. Eur J Neurosci. 17: 1329-37. PMID: 12713636
- The beta3 nicotinic receptor subunit: a component of alpha-conotoxin MII-binding nicotinic acetylcholine receptors that modulate dopamine release and related behaviors. | Cui, C., et al. 2003. J Neurosci. 23: 11045-53. PMID: 14657161
- Comparative proteomic analysis of de-N-glycosylated serum from hepatitis B carriers reveals polypeptides that correlate with disease status. | Comunale, MA., et al. 2004. Proteomics. 4: 826-38. PMID: 14997503
- Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors. | McIntosh, JM., et al. 2004. Mol Pharmacol. 65: 944-52. PMID: 15044624
- The subunit composition and pharmacology of alpha-Conotoxin MII-binding nicotinic acetylcholine receptors studied by a novel membrane-binding assay. | Salminen, O., et al. 2005. Neuropharmacology. 48: 696-705. PMID: 15814104
- Pharmacology of alpha-conotoxin MII-sensitive subtypes of nicotinic acetylcholine receptors isolated by breeding of null mutant mice. | Salminen, O., et al. 2007. Mol Pharmacol. 71: 1563-71. PMID: 17341654
- Synthesis and characterization of 125I-alpha-conotoxin ArIB[V11L;V16A], a selective alpha7 nicotinic acetylcholine receptor antagonist. | Whiteaker, P., et al. 2008. J Pharmacol Exp Ther. 325: 910-9. PMID: 18323456
- Analysis of somatic and salivary gland antigens of third stage larvae of Rhinoestrus spp. (Diptera, Oestridae). | Milillo, P., et al. 2010. Exp Parasitol. 124: 361-4. PMID: 19948170
- Increases in the expression levels of aquaporin-2 and aquaporin-3 in the renal collecting tubules alleviate dehydration associated with polyuria in diabetes mellitus. | Satake, M., et al. 2010. Biol Pharm Bull. 33: 1965-70. PMID: 21139234
- Cross Talk between α7 and α3β4 Nicotinic Receptors Prevents Their Desensitization in Human Chromaffin Cells. | Jiménez-Pompa, A., et al. 2022. J Neurosci. 42: 1173-1183. PMID: 34965978
Inhibitor of:
cathepsin B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Leupeptin trifluoroacetate salt, 1 mg | sc-215243 | 1 mg | $79.00 | |||
Leupeptin trifluoroacetate salt, 5 mg | sc-215243A | 5 mg | $155.00 | |||
Leupeptin trifluoroacetate salt, 10 mg | sc-215243B | 10 mg | $255.00 | |||
Leupeptin trifluoroacetate salt, 25 mg | sc-215243C | 25 mg | $455.00 | |||
Leupeptin trifluoroacetate salt, 50 mg | sc-215243D | 50 mg | $800.00 | |||
Leupeptin trifluoroacetate salt, 100 mg | sc-215243E | 100 mg | $1600.00 |