Molecular structure of Leukotriene E4, CAS Number: 75715-89-8
Leukotriene E4 (CAS 75715-89-8)
Alternate Names:
LTE4
Application:
Leukotriene E4 is a potent eicosanoid lipid mediator with multiple biological functions
CAS Number:
75715-89-8
Molecular Weight:
439.61
Molecular Formula:
C23H37NO5S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Leukotriene E4 (LTE4) is a lipid mediator that originates from arachidonic acid (AA) and serves a role in numerous physiological processes. The synthesis of LTE4 involves the intricate participation of the enzyme 5-lipoxygenase (5-LOX). While the exact mechanism of action for leukotriene E4 remains incompletely understood, it is known to bind to and activate the G protein-coupled receptor CysLT1. This receptor is expressed on various cell types, including mast cells, eosinophils, and neutrophils.
Leukotriene E4 (CAS 75715-89-8) References
- Prostaglandins and leukotrienes: advances in eicosanoid biology. | Funk, CD. 2001. Science. 294: 1871-5. PMID: 11729303
- Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma. | Sakata, K. and Bäck, M. 2002. Eur J Pharmacol. 436: 119-26. PMID: 11834255
- Clinical features of asthmatic patients with increased urinary leukotriene E4 excretion (hyperleukotrienuria): Involvement of chronic hyperplastic rhinosinusitis with nasal polyposis. | Higashi, N., et al. 2004. J Allergy Clin Immunol. 113: 277-83. PMID: 14767442
- Urinary leukotriene E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects. | Christie, PE., et al. 1991. Am Rev Respir Dis. 143: 1025-9. PMID: 1850964
- Increased leukotriene E4 excretion in systemic mastocytosis. | Butterfield, JH. 2010. Prostaglandins Other Lipid Mediat. 92: 73-6. PMID: 20380889
- Urinary leukotriene E4 levels during early and late asthmatic responses. | Manning, PJ., et al. 1990. J Allergy Clin Immunol. 86: 211-20. PMID: 2166758
- Leukotriene E4 elimination and metabolism in normal human subjects. | Sala, A., et al. 1990. J Biol Chem. 265: 21771-8. PMID: 2174886
- Urinary Leukotriene E4 to Determine Aspirin Intolerance in Asthma: A Systematic Review and Meta-Analysis. | Hagan, JB., et al. 2017. J Allergy Clin Immunol Pract. 5: 990-997.e1. PMID: 28202405
- The effects of inhaled leukotriene E4 on the airway responsiveness to histamine in subjects with asthma and normal subjects. | Arm, JP., et al. 1988. J Allergy Clin Immunol. 82: 654-60. PMID: 2844876
- Leukotriene E4 induces airflow obstruction and mast cell activation through the cysteinyl leukotriene type 1 receptor. | Lazarinis, N., et al. 2018. J Allergy Clin Immunol. 142: 1080-1089. PMID: 29518425
- In vivo metabolism of leukotriene C4 in man: urinary excretion of leukotriene E4. | Orning, L., et al. 1985. Biochem Biophys Res Commun. 130: 214-20. PMID: 2992461
- Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4. | Dahlén, SE., et al. 1983. Proc Natl Acad Sci U S A. 80: 1712-6. PMID: 6300870
- Validation and application of a new simple strategy for measurements of urinary leukotriene E4 in humans. | Kumlin, M., et al. 1995. Clin Exp Allergy. 25: 467-79. PMID: 7553251
Activator of:
CysLT1 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Leukotriene E4, 50 µg | sc-201050 | 50 µg | $211.00 | |||
Leukotriene E4, 1 mg | sc-201050A | 1 mg | $3641.00 | |||
Leukotriene E4, 5 mg | sc-201050B | 5 mg | $16646.00 | |||
Leukotriene E4, 10 mg | sc-201050C | 10 mg | $31212.00 |