Leukotriene B4-dimethyl Amide (CAS 83024-92-4)
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Leukotrienes comprise a family of endogenous metabolites of certain fatty acids and are related to thromboxanes and prostaglandins. They are potent eicosanoid lipid mediators that play numerous roles in inflammation, immunological functions and maintaining biological homeostasis. Leukotrienes possess a conjugated triene structure which gives them their name. They are generally isolated from leukocytes and primarily act through specific G protein-coupled receptors. Leukotriene B4-dimethyl Amide is a Leukotriene B4 antagonist. It has been shown to inhibit binding of [3H]-LTB4 to guinea pig lung membranes and to antagonize the degranulation response to LTB4 in rabbit PMNL acting, most likely, via receptor desensitization. It is a partial agonist at higher concentrations.
Leukotriene B4-dimethyl Amide (CAS 83024-92-4) References
- Prostaglandins and leukotrienes: advances in eicosanoid biology. | Funk, CD. 2001. Science. 294: 1871-5. PMID: 11729303
- Modulation of ligand binding to leukotriene B4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents. | Falcone, RC. and Aharony, D. 1990. J Pharmacol Exp Ther. 255: 565-71. PMID: 2173748
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Leukotriene B4-dimethyl Amide, 50 µg | sc-200702 | 50 µg | $304.00 |