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Leuhistin (CAS 129085-76-3)

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Alternate Names:
(2R,3S)-3-Amino-2-hydroxy-2-(1H-imidazol-4-ylmethyl)-5-methylhexanoic acid
Application:
Leuhistin is an inhibitor of aminopeptidase N (CD13)
CAS Number:
129085-76-3
Molecular Weight:
241.3
Molecular Formula:
C11H19N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Leuhistin is a chemical that functions as a potent inhibitor of histone deacetylase. It exerts its mechanism of action by binding to the active site of histone deacetylase enzymes, thereby preventing the deacetylation of histone proteins. This inhibition leads to an increase in histone acetylation, resulting in altered chromatin structure and gene expression. By modulating the acetylation status of histones, Leuhistin may play a role in regulating various cellular processes, including transcription, DNA repair, and cell cycle progression. Its ability to target histone deacetylase enzymes may be useful for studying the epigenetic regulation of gene expression and its impact on cellular function. In development applications, Leuhistin′s mechanism of action at the molecular level provides insights into the complex mechanisms underlying gene regulation and chromatin dynamics.


Leuhistin (CAS 129085-76-3) References

  1. Puromycin-sensitive alanyl aminopeptidase from human liver cytosol: purification and characterization.  |  Yamamoto, Y., et al. 2000. Forensic Sci Int. 113: 143-6. PMID: 10978616
  2. Midgut exopeptidase activities in Aedes aegypti are induced by blood feeding.  |  Noriega, FG., et al. 2002. J Insect Physiol. 48: 205-212. PMID: 12770120
  3. Reversal of angiotensin II-stimulated collagen gel contraction in cardiac fibroblasts by aminopeptidase inhibition.  |  Lijnen, PJ., et al. 2005. J Cardiovasc Pharmacol. 45: 68-73. PMID: 15613982
  4. CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells.  |  Chang, YW., et al. 2005. Int J Cancer. 116: 243-52. PMID: 15812828
  5. Leuhistin, a new inhibitor of aminopeptidase M, produced by Bacillus laterosporus BMI156-14F1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.  |  Aoyagi, T., et al. 1991. J Antibiot (Tokyo). 44: 573-8. PMID: 1676997
  6. Leuhistin, a new inhibitor of aminopeptidase M, produced by Bacillus laterosporus BMI156-14F1. II. Structure determination of leuhistin.  |  Yoshida, S., et al. 1991. J Antibiot (Tokyo). 44: 579-81. PMID: 1676998
  7. Biosynthetic study of leuhistin, a new inhibitor of aminopeptidase M.  |  Yoshida, S., et al. 1991. J Antibiot (Tokyo). 44: 683-4. PMID: 1676999
  8. Probestin, a new inhibitor of aminopeptidase M, produced by Streptomyces azureus MH663-2F6. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.  |  Aoyagi, T., et al. 1990. J Antibiot (Tokyo). 43: 143-8. PMID: 1968900
  9. Control of APN/CD13 and NEP/CD10 on sperm motility.  |  Subirán, N., et al. 2010. Asian J Androl. 12: 899-902. PMID: 20852652
  10. Effect of Aminopeptidase N on functions and fertility of mouse spermatozoa in vitro.  |  Khatun, A., et al. 2018. Theriogenology. 118: 182-189. PMID: 29913423
  11. Functional separation of dipeptide transport and hydrolysis in kidney brush border membrane vesicles.  |  Daniel, H. and Adibi, SA. 1994. FASEB J. 8: 753-9. PMID: 8050675
  12. Inhibition of tumor cell invasion and matrix degradation by aminopeptidase inhibitors.  |  Fujii, H., et al. 1996. Biol Pharm Bull. 19: 6-10. PMID: 8820902
  13. Alanyl aminopeptidase from human seminal plasma: purification, characterization, and immunohistochemical localization in the male genital tract.  |  Huang, K., et al. 1997. J Biochem. 122: 779-87. PMID: 9399582
  14. Characterization of aminopeptidase N from the brush border membrane of the larvae midgut of silkworm, Bombyx mori as a zinc enzyme.  |  Hua, G., et al. 1998. Biochim Biophys Acta. 1383: 301-10. PMID: 9602161
  15. Isolation and characterization of an alanyl aminopeptidase from rat liver cytosol as a puromycin-sensitive enkephalin-degrading aminopeptidase.  |  Yamamoto, Y., et al. 1998. Biol Chem. 379: 711-9. PMID: 9687021

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Leuhistin, 500 µg

sc-202692A
500 µg
$208.00

Leuhistin, 1 mg

sc-202692
1 mg
$624.00