Date published: 2026-1-31

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Leptin (human), (recombinant) (CAS 177404-21-6)

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Alternate Names:
OB gene product; OB Protein; Obesity Protein; OBS; Obesity factor
Application:
Leptin (human), (recombinant) is a key protein used in obesity studies
CAS Number:
177404-21-6
Molecular Weight:
~16000
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Leptin (human), (recombinant) (aka OB protein, or Obesity factor protein) is a 16-kDa peptide hormone secreted from white adipocytes and implicated in the regulation of food intake and energy balance. Leptin (human), (recombinant) provides the key afferent signal from fat cells in the feedback system that controls body fat stores. Leptin (human), (recombinant) is produced in E.Coli as a single, non-glycosylated, polypeptide chain containing 146 amino acids and having a molecular mass of approximately 16 kDa. The Leptin (human), (recombinant) protein is purified by proprietary chromatographic techniques.Biological Activity is evidenced by inducing proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor.


Leptin (human), (recombinant) (CAS 177404-21-6) References

  1. Biologic response to peripheral and central administration of recombinant human leptin in dogs.  |  LeBel, C., et al. 1999. Obes Res. 7: 577-85. PMID: 10574517
  2. Effect of human recombinant leptin on lipid handling by fully differentiated Caco-2 cells.  |  Stan, S., et al. 2001. FEBS Lett. 508: 80-4. PMID: 11707272
  3. Effect of leptin on progesterone, human chorionic gonadotropin, and interleukin-6 secretion by human term trophoblast cells in culture.  |  Cameo, P., et al. 2003. Biol Reprod. 68: 472-7. PMID: 12533410
  4. Leptin in human physiology and therapeutics.  |  Dardeno, TA., et al. 2010. Front Neuroendocrinol. 31: 377-93. PMID: 20600241
  5. Recombinant human leptin attenuates stress axis activity in common carp (Cyprinus carpio L.).  |  Gorissen, M., et al. 2012. Gen Comp Endocrinol. 178: 75-81. PMID: 22543190
  6. Recombinant human leptin induces growth inhibition and apoptosis in human gastric cancer MGC-803 cells.  |  Wu, N., et al. 2013. Clin Exp Med. 13: 305-14. PMID: 23001141
  7. Pegylated Human Leptin D23L Mutant-Preparation and Biological Activity In Vitro and In Vivo in Male ob/ob Mice.  |  Gertler, A. and Solomon, G. 2019. Endocrinology. 160: 891-898. PMID: 30802285
  8. Leptin increases hepatic triglyceride export via a vagal mechanism in humans.  |  Metz, M., et al. 2022. Cell Metab. 34: 1719-1731.e5. PMID: 36220067
  9. Does hypoleptinemia trigger entrapment in anorexia nervosa? Etiological and clinical considerations.  |  Hebebrand, J., et al. 2024. Eur Eat Disord Rev. 32: 557-574. PMID: 38303556
  10. Development of radioimmunoassay for human leptin.  |  Hosoda, K., et al. 1996. Biochem Biophys Res Commun. 221: 234-9. PMID: 8619839

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Leptin (human), (recombinant), 1 mg

sc-471283
1 mg
$194.00

Leptin (human), (recombinant), 5 mg

sc-471283A
5 mg
$588.00