Molecular structure of LED209, CAS Number: 245342-14-7
LED209 (CAS 245342-14-7)
Alternate Names:
N-phenyl-4-[[(phenylamino)thioxomethyl]amino]-benzenesulfonamide
Application:
LED209 is a potent conserved membrane histidine sensor kinase
CAS Number:
245342-14-7
Molecular Weight:
383.48
Molecular Formula:
C19H17N3O2S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bacterial pathogens require the conserved membrane histidine sensor kinase (QseC) to detect both host-derived adrenergic signals and the bacterial autoinducer-3 (AI-3), thus activating a signaling cascade that induces virulence gene expression.1 LED209 is a potent QseC inhibitor that blocks both norepinephrine- and epinephrine-triggered QseC-dependent virulence gene expression at 5 pM in vitro.2 While LED209 inhibits virulence of enterohemorrhagic E. coli, S. typhimurium, and F. tularensis, it does not inhibit pathogen growth, a highly desirable feature of antimicrobial agents to prevent drug resistance.2
LED209 (CAS 245342-14-7) References
1 Sperandio, V., Torres, A.G., Jarvis, B., et al. Bacteria-host communication: The language of hormones. Proc Natl Acad Sci USA 100(15) 8951-8956 (2003). 2 Rasko, D.A., Moreira, C.G., Li, D.R., et al. Targeting QseC signaling and virulence for antibiotic development. Science 321 1078-1080 (20Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LED209, 1 mg | sc-205368 | 1 mg | $18.00 | |||
LED209, 5 mg | sc-205368A | 5 mg | $75.00 |