Molecular structure of LDS 751, CAS Number: 181885-68-7
LDS 751 (CAS 181885-68-7)
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Alternate Names:
2-[4-[4-(dimethylamino)phenyl]-1,3-butadienyl]-3-ethylbenzothiazolium perchlorate
Application:
LDS 751 is a fluorescent cell-permeant nucleic acid stain
CAS Number:
181885-68-7
Molecular Weight:
471.98
Molecular Formula:
C25H30N3•ClO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LDS 751 is a fluorescent cell-permeant nucleic acid stain that can be well excited with 488 nm laser line although it has a peak excitation at ~543 nm on dsDNA. It might be an alternative to DRAQ 5™, useful in multicolor analyses due to its long wavelength emission maximum (~712 nm). Upon binding to dsDNA LDS 751 has ~20-fold fluorescence enhancement. It has been reported that LDS-751 is excluded from the nucleus and binds the polarized membranes of mitochondria. Thiazole orange (an RNA dye) and LDS-751 (a DNA dye) composition has been used to separate reticulocytes from other cell populations. LDS 751 has been also used to separate red blood cells from nucleated cells.
LDS 751 (CAS 181885-68-7) References
- Staining of cellular mitochondria with LDS-751. | Snyder, DS. and Small, PL. 2001. J Immunol Methods. 257: 35-40. PMID: 11687236
- Elevation of P-glycoprotein function by a catechin in green tea. | Wang, EJ., et al. 2002. Biochem Biophys Res Commun. 297: 412-8. PMID: 12237135
- Bone marrow cell differential counts obtained by multidimensional flow cytometry. | Terstappen, LW. and Levin, J. 1992. Blood Cells. 18: 311-30; discussion 331-2. PMID: 1450429
- Interaction of LDS-751 with P-glycoprotein and mapping of the location of the R drug binding site. | Lugo, MR. and Sharom, FJ. 2005. Biochemistry. 44: 643-55. PMID: 15641790
- Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs. | Lugo, MR. and Sharom, FJ. 2005. Biochemistry. 44: 14020-9. PMID: 16229491
- Comparison of sample fixation and the use of LDS-751 or anti-CD45 for leukocyte identification in mouse whole blood for flow cytometry. | Maes, ML., et al. 2007. J Immunol Methods. 319: 79-86. PMID: 17187818
- Interaction of LDS-751 with the drug-binding site of P-glycoprotein: a Trp fluorescence steady-state and lifetime study. | Lugo, MR. and Sharom, FJ. 2009. Arch Biochem Biophys. 492: 17-28. PMID: 19818729
- Lipid bilayer properties control membrane partitioning, binding, and transport of p-glycoprotein substrates. | Clay, AT. and Sharom, FJ. 2013. Biochemistry. 52: 343-54. PMID: 23268645
- Discriminating between damaged and intact cells in fixed flow cytometric samples. | Terstappen, LW., et al. 1988. Cytometry. 9: 477-84. PMID: 2460298
- Quantifying permeabilization and activity recovery of Bacillus spores in adverse conditions for growth. | Trunet, C., et al. 2019. Food Microbiol. 81: 115-120. PMID: 30910082
- Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter. | Robey, RW., et al. 2021. Sci Rep. 11: 24150. PMID: 34921178
- Flow cytometric determination of CD11b upregulation in vivo. | Repo, H., et al. 1993. J Immunol Methods. 164: 193-202. PMID: 8370926
- Transport of LDS-751 from the cytoplasmic leaflet of the plasma membrane by the rhodamine-123-selective site of P-glycoprotein. | Shapiro, AB. and Ling, V. 1998. Eur J Biochem. 254: 181-8. PMID: 9652412
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LDS 751, 5 mg | sc-391156 | 5 mg | $124.00 |