Molecular structure of Lck Inhibitor III, CAS Number: 1188890-30-3
Lck Inhibitor III (CAS 1188890-30-3)
Alternate Names:
2-(1H-Benzo[d]imidazol-1-yl)-N-(5-methoxy-2-methylphenyl)-6-(2-morpholinoethoxy)pyrimidin-4-amine, hydrate
Application:
Lck Inhibitor III is a cell-permeable, tri-substituted amine
CAS Number:
1188890-30-3
Molecular Weight:
478.55
Molecular Formula:
C25H28N6O3•H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lck Inhibitor III is a cell-permeable, ATP binding site-targeting, tri-substituted pyrimidine that acts as a Lck (lymphocyte specific kinase) inhibitor (IC50 = 867 nM; [ATP] = 10 μM). Has been reported to block IL-2 release in Jurkat E6-1 T cell line (IC50 = 1.27 μM) stimulated by CD3 cross-linking and PMA. Although less potent than Lck Inhibitor II, it exhibits much improved aqueous solubility (27 µg/ml in 50 mM PBS, pH 7.4, ionic strength 0.15 M).
Lck Inhibitor III (CAS 1188890-30-3) References
- The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck). | Sabat, M., et al. 2006. Bioorg Med Chem Lett. 16: 5973-7. PMID: 16997556
- Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase. | Sibilski, C., et al. 2013. J Biol Chem. 288: 35237-52. PMID: 24158441
- Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint. | Tamehiro, N., et al. 2015. PLoS One. 10: e0131047. PMID: 26114424
Inhibitor of:
Enzyme, and Lck.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lck Inhibitor III, 5 mg | sc-311372 | 5 mg | $660.00 |