Molecular structure of LC-SDA (NHS-LC-Diazirine)
LC-SDA (NHS-LC-Diazirine)
Alternate Names:
Succinimidyl 6-(4,4′-azipentanamido)hexanoate
Application:
LC-SDA (NHS-LC-Diazirine) is an NHS-diazirine based photoreactive crosslinker
Molecular Weight:
338.36
Molecular Formula:
C15H22N4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LC-SDA (NHS-LC-Diazirine) is an amine and photoreactive, membrane permeable, heterobifunctional crosslinker with a 12.5 Angstrom spacer arm. The diazirine photoreactive group has improved photostability over aryl azides, yet is more efficiently activated by long-wave UV light (330-370nm). Activation of the diazirine releases nitrogen to produce a highly reactive carbene intermediate, which then indiscriminately bonds with nearby functional group.
LC-SDA (NHS-LC-Diazirine) References
- Growth cones turn and migrate up an immobilized gradient of the laminin IKVAV peptide. | Adams, DN., et al. 2005. J Neurobiol. 62: 134-47. PMID: 15452851
- Interactions of the transmembrane polymeric rings of the Salmonella enterica serovar Typhimurium type III secretion system. | Sanowar, S., et al. 2010. mBio. 1: PMID: 20824104
- Claudin-2 forms homodimers and is a component of a high molecular weight protein complex. | Van Itallie, CM., et al. 2011. J Biol Chem. 286: 3442-50. PMID: 21098027
- The stoichiometry of scaffold complexes in living neurons - DLC2 functions as a dimerization engine for GKAP. | Moutin, E., et al. 2014. J Cell Sci. 127: 3451-62. PMID: 24938595
- A novel RNA polymerase-binding protein that interacts with a sigma-factor docking site. | Wang Erickson, AF., et al. 2017. Mol Microbiol. 105: 652-662. PMID: 28598017
- A microtubule crosslinking protocol for integrative structural modeling activities. | Rafiei, A. and Schriemer, DC. 2019. Anal Biochem. 586: 113416. PMID: 31499019
- The human milk protein-lipid complex HAMLET disrupts glycolysis and induces death in Streptococcus pneumoniae. | Roche-Hakansson, H., et al. 2019. J Biol Chem. 294: 19511-19522. PMID: 31694917
- Molecular anatomy of the receptor binding module of a bacteriophage long tail fiber. | Islam, MZ., et al. 2019. PLoS Pathog. 15: e1008193. PMID: 31856258
- Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor. | Srivastava, M., et al. 2020. Nat Commun. 11: 3896. PMID: 32753727
- Strategy for Conjugating Oligopeptides to Mesoporous Silica Nanoparticles Using Diazirine-Based Heterobifunctional Linkers. | Khan, MA., et al. 2022. Nanomaterials (Basel). 12: PMID: 35214937
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LC-SDA (NHS-LC-Diazirine), 50 mg | sc-397279 | 50 mg | $800.00 |