LBP1 Antibody (327C1a): sc-81310

LBP1 Antibody (327C1a) is a mouse monoclonal IgG1 antibody that detects LBP1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-LBP1 antibody (327C1a) is available as a non-conjugated format. LBP1, also known as Upstream-binding protein 1, UBP1, LBP1A, or LBP1B, is a 540 amino acid protein belonging to the grainyhead transcription factor family, which plays a crucial role in various cellular processes. LBP1 is primarily located in the nucleus, functioning as a transcriptional activator, regulating the expression of key genes such as CYP11A1 in the placenta and activating the hemoglobin globin promoter in erythroid cells. Nuclear localization of LBP1 is essential for gene regulation, allowing direct interaction with DNA and other transcriptional machinery. LBP1 also represses HIV-1 transcription by binding to TFIID, preventing interaction with the viral promoter region. Absence of LBP1 has been linked to uterine growth retardation in mouse embryos, highlighting critical involvement in extraembryonic angiogenesis. LBP1 can form homodimers and heterodimers with LBP-9, which negatively regulates LBP1 expression, further illustrating the complexity of regulatory mechanisms.

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LBP1 Antibody (327C1a) References:

1. Defective extraembryonic angiogenesis in mice lacking LBP-1a, a member of the grainyhead family of transcription factors.  |  Parekh, V., et al. 2004. Mol Cell Biol. 24: 7113-29. PMID: 15282311
2. LBP proteins modulate SF1-independent expression of P450scc in human placental JEG-3 cells.  |  Huang, N. and Miller, WL. 2005. Mol Endocrinol. 19: 409-20. PMID: 15471945
3. Heterodimerization with LBP-1b is necessary for nuclear localization of LBP-1a and LBP-1c.  |  Sato, F., et al. 2005. Genes Cells. 10: 861-70. PMID: 16115195
4. A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro.  |  Parada, CA., et al. 1995. J Biol Chem. 270: 2274-83. PMID: 7836461
5. Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro.  |  Yoon, JB., et al. 1994. Mol Cell Biol. 14: 1776-85. PMID: 8114710

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LBP1 Antibody (327C1a) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-LBP1 Antibody (327C1a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LBP1 Antibody (327C1a) Specifications

Alternate Product Name: LBP1

Product Clone Name: 327C1a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: LBP1

Epitope Species: human

Product Reactivity/Detection: LBP1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for LBP1 Antibody (327C1a): N/A