Molecular structure of Lawesson reagent, CAS Number: 19172-47-5
Lawesson reagent (CAS 19172-47-5)
Application:
Lawesson reagent is a thiation reagent
CAS Number:
19172-47-5
Purity:
≥97%
Molecular Weight:
404.47
Molecular Formula:
C14H14O2P2S4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lawesson reagent is a chemical compound used as a reagent in organic synthesis. The reagent functions by reacting with the carbonyl group of the substrate, forming an intermediate that undergoes a rearrangement to yield the desired thiofunctionalized product. This process involves the formation of a new carbon-sulfur bond, which is a key step in the functionalization of organic molecules. The mechanism of action of Lawesson reagent involves the activation of the carbonyl group through a nucleophilic attack, followed by sulfur insertion and subsequent rearrangement.
Lawesson reagent (CAS 19172-47-5) References
- Synthesis of novel acetal thia-cage compounds. | Wu, CY., et al. 2001. J Org Chem. 66: 4610-8. PMID: 11421781
- Syntheses, X-ray Crystal Structures, and Spectroscopic Properties of New Nickel Dithiolenes and Related Compounds. | Bigoli, F., et al. 1997. Inorg Chem. 36: 1218-1226. PMID: 11669689
- [Application of high resolution mass spectra to the analysis of alpha-thiocarbonylthioformamides]. | Zou, JP., et al. 2002. Guang Pu Xue Yu Guang Pu Fen Xi. 22: 883-5. PMID: 12914153
- Biphenalenylidene: the forgotten bistricyclic aromatic ene. A theoretical study. | Pogodin, S. and Agranat, I. 2003. J Am Chem Soc. 125: 12829-35. PMID: 14558831
- Synthesis of isolable thiirane-2-thione (alpha-dithiolactone) from thioketene S-oxide. | Okuma, K., et al. 2004. J Am Chem Soc. 126: 9508-9. PMID: 15291532
- Synthesis and reaction of alpha-dithiolactone. | Shigetomi, T., et al. 2006. Chemistry. 12: 7742-8. PMID: 16819724
- Unprecedented formation of novel phosphonodithioate ligands from diferrocenyldithiadiphosphetane disulfide. | Barranco, EM., et al. 2008. Inorg Chem. 47: 6913-8. PMID: 18598024
- Formation and reactivity of phosphorus-selenium rings. | Hua, G. and Woollins, JD. 2009. Angew Chem Int Ed Engl. 48: 1368-77. PMID: 19053094
- Thionations using a P4S10-pyridine complex in solvents such as acetonitrile and dimethyl sulfone. | Bergman, J., et al. 2011. J Org Chem. 76: 1546-53. PMID: 21341727
- [Investigation of the intramolecular cyclization of the thiophene substituted cyclohexane skeleton gamma-oxocarboxylic acid and synthesis of some N-heteroaryl isoindole derivatives]. | Csende, F. 2011. Acta Pharm Hung. 81: 59-62. PMID: 21800711
- Efficient access to novel androsteno-17-(1',3',4')-oxadiazoles and 17β-(1',3',4')-thiadiazoles via N-substituted hydrazone and N,N'-disubstituted hydrazine intermediates, and their pharmacological evaluation in vitro. | Kovács, D., et al. 2015. Eur J Med Chem. 98: 13-29. PMID: 25993309
- Evaluation of thioamides, thiolactams and thioureas as hydrogen sulfide (H2S) donors for lowering blood pressure. | Zaorska, E., et al. 2019. Bioorg Chem. 88: 102941. PMID: 31039470
- Asymmetric Organocatalytic [4 + 1] Annulations Involving a Polarity Reversal Process: A Tandem Catalytic Approach to Highly Functionalized Spiropyrazolone Derivatives. | Tan, CY., et al. 2020. J Org Chem. 85: 594-602. PMID: 31790224
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lawesson reagent, 10 g | sc-252948 | 10 g | $31.00 | |||
Lawesson reagent, 25 g | sc-252948A | 25 g | $48.00 | |||
Lawesson reagent, 100 g | sc-252948B | 100 g | $102.00 | |||
Lawesson reagent, 250 g | sc-252948C | 250 g | $230.00 | |||
Lawesson reagent, 500 g | sc-252948D | 500 g | $358.00 | |||
Lawesson reagent, 1 kg | sc-252948E | 1 kg | $714.00 |