Molecular structure of Lavendustin C, CAS Number: 125697-93-0
Lavendustin C (CAS 125697-93-0)
Application:
Lavendustin C is an inhibitor of CaMKII
CAS Number:
125697-93-0
Purity:
≥98%
Molecular Weight:
275.30
Molecular Formula:
C14H13NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lavendustin C inhibits Ca2+/calmodulin kinase II (IC50=0.2 μM), EGF receptor tyrosine kinase (IC50=44 nM) and Src(IC50=0.5 μM). Lavendustin C also inhibits crystal-stimulated neutrophil degranulation (10-150 μM).
Lavendustin C (CAS 125697-93-0) References
- Signaling events leading to crassulacean acid metabolism induction in the common ice plant. | Taybi, T. and Cushman, JC. 1999. Plant Physiol. 121: 545-56. PMID: 10517846
- Increased cytosolic Ca(2+) concentration in endothelial cells by calmodulin antagonists. | Watanabe, H., et al. 1999. Biochem Biophys Res Commun. 265: 697-702. PMID: 10600483
- Endotoxin increases intercellular resistance in microvascular endothelial cells by a tyrosine kinase pathway. | Lidington, D., et al. 2000. J Cell Physiol. 185: 117-25. PMID: 10942525
- Calcium/calmodulin-dependent protein kinase II phosphorylates and regulates the Drosophila eag potassium channel. | Wang, Z., et al. 2002. J Biol Chem. 277: 24022-9. PMID: 11980904
- Ca2+ channel remodeling in perfused heart: Effects of mechanical work and interventions affecting Ca2+ cycling on sarcolemmal and sarcoplasmic reticulum Ca2+ channels. | Zucchi, R., et al. 2002. FASEB J. 16: 1976-8. PMID: 12397086
- Involvement of Ca2+/calmodulin-dependent protein kinase II in endothelial NO production and endothelium-dependent relaxation. | Schneider, JC., et al. 2003. Am J Physiol Heart Circ Physiol. 284: H2311-9. PMID: 12560211
- Augmentation of insulin-stimulated ANP release through tyrosine kinase and PI 3-kinase in diabetic rats. | Bai, GY., et al. 2006. Peptides. 27: 2756-63. PMID: 16828931
- Functional, genetic and bioinformatic characterization of a calcium/calmodulin kinase gene in Sporothrix schenckii. | Valle-Aviles, L., et al. 2007. BMC Microbiol. 7: 107. PMID: 18047672
- Involvement of CaM kinase II in the impairment of endothelial function and eNOS activity in aortas of Type 2 diabetic rats. | Kobayashi, T., et al. 2012. Clin Sci (Lond). 123: 375-86. PMID: 22494112
- Effects of the phytoestrogen, genistein, and protein tyrosine kinase inhibitor-dependent mechanisms on steroidogenesis and estrogen receptor expression in porcine granulosa cells of medium follicles. | Nynca, A., et al. 2013. Domest Anim Endocrinol. 44: 10-8. PMID: 22920265
- The Effects of Phytoestrogen Genistein on Steroidogenesis and Estrogen Receptor Expression in Porcine Granulosa Cells of Large Follicles. | Nynca, A., et al. 2015. Folia Biol (Krakow). 63: 119-28. PMID: 26255463
- Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor. | Burt, HM., et al. 1994. J Leukoc Biol. 55: 112-9. PMID: 8283135
- The effect of tyrosine kinase inhibitors on IgE-mediated histamine release from human lung mast cells and basophils. | Lavens-Phillips, SE., et al. 1998. Inflamm Res. 47: 137-43. PMID: 9562339
Inhibitor of:
CaMKII, EGFR, Enzyme, Ser/Thr Protein Kinase, SRC, and Tyk.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lavendustin C, 1 mg | sc-202207 | 1 mg | $84.00 | |||
Lavendustin C, 5 mg | sc-202207B | 5 mg | $184.00 | |||
Lavendustin C, 10 mg | sc-202207A | 10 mg | $326.00 | |||
Lavendustin C, 50 mg | sc-202207C | 50 mg | $1428.00 |