Molecular structure of Lavendustin B, CAS Number: 125697-91-8
Lavendustin B (CAS 125697-91-8)
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Alternate Names:
N,N-bis(2′-Hydroxybenzyl)-3-aminosalicylic acid
Application:
Lavendustin B is a tyrosine kinase inhibitor
CAS Number:
125697-91-8
Purity:
≥97%
Molecular Weight:
365.4
Molecular Formula:
C21H19NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lavendustin B is a weak tyrosine kinase inhibitor that has been used as a negative control for lavendustin A (sc-200539). Lavendustin A strongly inhibits epidermal growth factor receptor-associated tyrosine kinase, competes with ATP, and is noncompetitive with the peptide.
Lavendustin B (CAS 125697-91-8) References
- Excitatory synaptogenesis between identified Lymnaea neurons requires extrinsic trophic factors and is mediated by receptor tyrosine kinases. | Hamakawa, T., et al. 1999. J Neurosci. 19: 9306-12. PMID: 10531435
- Insulin inhibits voltage-dependent calcium influx into rod photoreceptors. | Stella, SL., et al. 2001. Neuroreport. 12: 947-51. PMID: 11303766
- Coupling of c-Src to large conductance voltage- and Ca2+-activated K+ channels as a new mechanism of agonist-induced vasoconstriction. | Alioua, A., et al. 2002. Proc Natl Acad Sci U S A. 99: 14560-5. PMID: 12391293
- Endogenous neurotrophins are required for the induction of GABAergic long-term potentiation in the neonatal rat hippocampus. | Gubellini, P., et al. 2005. J Neurosci. 25: 5796-802. PMID: 15958746
- Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. | Onoda, T., et al. 1989. J Nat Prod. 52: 1252-7. PMID: 2614420
- Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase. | Agharbaoui, FE., et al. 2016. Eur J Med Chem. 123: 673-683. PMID: 27517812
- Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. | Hu, DE. and Fan, TP. 1995. Br J Pharmacol. 114: 262-8. PMID: 7533611
- Tyrosine phosphorylation during synapse formation between identified leech neurons. | Catarsi, S., et al. 1995. J Physiol. 485 (Pt 3): 775-86. PMID: 7562616
- Chloride efflux during the progesterone-initiated human sperm acrosome reaction is inhibited by lavendustin A, a tyrosine kinase inhibitor. | Meizel, S. and Turner, KO. 1996. J Androl. 17: 327-30. PMID: 8889693
- Role of nitric oxide, prostaglandins and tyrosine kinase in vascular endothelial growth factor-induced increase in vascular permeability in mouse skin. | Fujii, E., et al. 1997. Naunyn Schmiedebergs Arch Pharmacol. 356: 475-80. PMID: 9349634
- Tyrosine kinase inhibitors block sperm-induced egg activation in Xenopus laevis. | Glahn, D., et al. 1999. Dev Biol. 205: 171-80. PMID: 9882505
Inhibitor of:
CSNK1A1L, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lavendustin B, 1 mg | sc-200595 | 1 mg | $64.00 | |||
Lavendustin B, 5 mg | sc-200595A | 5 mg | $249.00 |