Molecular structure of Latanoprost, CAS Number: 130209-82-4
Latanoprost (CAS 130209-82-4)
See product citations (2)
Alternate Names:
Isopropyl (5Z,9α,11α,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate;Xalatan
Application:
Latanoprost is a prodrug of 17-phenyl-13,14-dihydro prostaglandin F2α
CAS Number:
130209-82-4
Purity:
≥98%
Molecular Weight:
432.59
Molecular Formula:
C26H40O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Latanoprost is a prodrug (isopropyl ester) of 17-phenyl-13,14-dihydro prostaglandin F2α. The free acid form is a potent agonist at PGF2αR (FP receptors). It is in pre-clinical use (research only) as a topical antiglaucoma agent and has been shown to reduce IOP (intraoccular pressure) Latanoprost is an activator of EP1 and EP3.
Latanoprost (CAS 130209-82-4) References
- Latanoprost increases the severity and recurrence of herpetic keratitis in the rabbit. | Kaufman, HE., et al. 1999. Am J Ophthalmol. 127: 531-6. PMID: 10334345
- Effects of topical latanoprost on optic nerve head circulation in rabbits, monkeys, and humans. | Ishii, K., et al. 2001. Invest Ophthalmol Vis Sci. 42: 2957-63. PMID: 11687542
- Reduction of intraocular pressure in mouse eyes treated with latanoprost. | Aihara, M., et al. 2002. Invest Ophthalmol Vis Sci. 43: 146-50. PMID: 11773025
- Comparison between isopropyl unoprostone and latanoprost by prostaglandin E(2)induction, affinity to prostaglandin transporter, and intraocular metabolism. | Kashiwagi, K., et al. 2002. Exp Eye Res. 74: 41-9. PMID: 11878817
- Conjunctival hyperemia in healthy subjects after short-term dosing with latanoprost, bimatoprost, and travoprost. | Stewart, WC., et al. 2003. Am J Ophthalmol. 135: 314-20. PMID: 12614748
- Effect of latanoprost on outflow facility in the mouse. | Crowston, JG., et al. 2004. Invest Ophthalmol Vis Sci. 45: 2240-5. PMID: 15223801
- In vitro comparison of cytoprotective and antioxidative effects of latanoprost, travoprost, and bimatoprost on conjunctiva-derived epithelial cells. | Guenoun, JM., et al. 2005. Invest Ophthalmol Vis Sci. 46: 4594-9. PMID: 16303954
- Effect of latanoprost on the expression of matrix metalloproteinases and their tissue inhibitors in human trabecular meshwork cells. | Oh, DJ., et al. 2006. Invest Ophthalmol Vis Sci. 47: 3887-95. PMID: 16936101
- Retinal ganglion cell neuroprotection in a rat model of glaucoma following brimonidine, latanoprost or combined treatments. | Hernández, M., et al. 2008. Exp Eye Res. 86: 798-806. PMID: 18394603
- Latanoprost-Eluting Contact Lenses in Glaucomatous Monkeys. | Ciolino, JB., et al. 2016. Ophthalmology. 123: 2085-92. PMID: 27586444
- Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Latanoprost Study Groups. | Camras, CB., et al. 1996. Ophthalmology. 103: 1916-24. PMID: 8942890
- The pharmacokinetics of a new antiglaucoma drug, latanoprost, in the rabbit. | Sjöquist, B., et al. 1998. Drug Metab Dispos. 26: 745-54. PMID: 9698288
- Effect of latanoprost on the extracellular matrix of the ciliary muscle. A study on cultured cells and tissue sections. | Ocklind, A. 1998. Exp Eye Res. 67: 179-91. PMID: 9733584
Activator of:
DP, EP1, EP3, IP Receptor, and PGF2alphaR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Latanoprost, 1 mg | sc-201354 | 1 mg | $58.00 | |||
Latanoprost, 5 mg | sc-201354A | 5 mg | $230.00 | |||
Latanoprost, 5 mg | sc-201354A-CW | 5 mg | $306.00 |