LARS2 Antibody (G-5): sc-514745

LARS2 Antibody (G-5) is a mouse monoclonal IgM antibody that detects LARS2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LARS2, also known as leucyl-tRNA synthetase 2, mitochondrial or LEURS, is a crucial 903 amino acid protein belonging to the class-I aminoacyl-tRNA synthetase family, primarily localized in the mitochondrial matrix. LARS2 plays a vital role in protein synthesis by catalyzing the aminoacylation of leucine to tRNA(Leu) through a two-step reaction. The first step involves the activation of leucine by ATP, resulting in an adenylate intermediate, which is then transferred to the 3′-end of the target tRNA. The specific sequence and orientation of the variable loop in tRNA(Leu) are essential for interaction with LARS2, ensuring accurate protein synthesis. Notably, LARS2 has been implicated in various neurological and metabolic disorders, including bipolar disorder and schizophrenia, where upregulation may lead to the production of a mutated tRNA(Leu) that undergoes aminoacylation. Additionally, increased levels of LARS2 have been associated with diabetes, suggesting a potential role in glucose intolerance. LARS2 (G-5) antibody is an invaluable tool for researchers investigating the functional implications of LARS2 in health and disease.

The preferred LARS2 antibody is LARS2 Antibody (G-9): sc-514454.