Molecular structure of LAQ824, CAS Number: 404951-53-7
LAQ824 (CAS 404951-53-7)
Alternate Names:
(E)-3-(4-(((2-(1H-indol-3-yl)ethyl)(2-hydroxyethyl)amino)methyl)phenyl)-N-hydroxyacrylamide
Application:
LAQ824 is an HDAC inhibitor affecting p21
CAS Number:
404951-53-7
Molecular Weight:
379.46
Molecular Formula:
C22H25N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
LAQ824 (NVP-LAQ824) is a novel HDAC inhibitor with IC50 of 32 nM. LAQ824 activates the p21 promoter with 50% of the maximal promoter activation (AC50) of 0.30 μM, which in turn, activates the p21 inhibitor gene. LAQ824 inhibits the cell growth of H1299, a non-small cell lung carcinoma line, and HCT116, a colon cancer cell line with IC50 of 0.15 μM and 0.01 μM, respectively. A recent study shows that LAQ824 induces chromatin changes at the level of the IL-10 gene promoter that lead to enhanced recruitment of the transcriptional repressors HDAC11 and PU.1 and inhibits IL-10 production in BALB/c murine macrophages.
LAQ824 (CAS 404951-53-7) References
1. Atadja P, et al. Cancer Res, 2004, 64(2), 689-695. 2. Wang H, et al. J Immuno, 2011, 186(7), 3986-3996.Inhibitor of:
Enzyme, and HDAC.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LAQ824, 10 mg | sc-364521 | 10 mg | $225.00 | |||
LAQ824, 50 mg | sc-364521A | 50 mg | $1000.00 |