Molecular structure of Lanatoside C, CAS Number: 17575-22-3
Lanatoside C (CAS 17575-22-3)
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Alternate Names:
Allocor; Cedilanid
Application:
Lanatoside C is A cardiotonic glycoside isolated from various species of Digitalis
CAS Number:
17575-22-3
Purity:
≥97%
Molecular Weight:
985.12
Molecular Formula:
C49H76O20
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lanatoside C is a cardiotonic glycoside isolated from various species of Digitalis. In laboratory studies, lanatoside C has demonstrated promising prospects in the fields of drug delivery, gene therapy, and tissue engineering. The precise mechanism underlying its actions is still under investigation. However, current understanding suggests that lanatoside C exerts its effects by impeding the function of specific enzymes and proteins responsible for regulating cell growth and differentiation. Moreover, it is believed to modulate the activity of various signaling pathways, including the MAPK, NF-κB, and PI3K pathways.
Lanatoside C (CAS 17575-22-3) References
- Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor-related apoptosis-inducing ligand and induces an alternative cell death pathway. | Badr, CE., et al. 2011. Neuro Oncol. 13: 1213-24. PMID: 21757445
- Antiviral activity of lanatoside C against dengue virus infection. | Cheung, YY., et al. 2014. Antiviral Res. 111: 93-9. PMID: 25251726
- Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma. | Crommentuijn, MH., et al. 2016. Mol Oncol. 10: 625-34. PMID: 26708508
- Lanatoside C suppressed colorectal cancer cell growth by inducing mitochondrial dysfunction and increased radiation sensitivity by impairing DNA damage repair. | Kang, MA., et al. 2016. Oncotarget. 7: 6074-87. PMID: 26756216
- Lanatoside C Promotes Foam Cell Formation and Atherosclerosis. | Shi, H., et al. 2016. Sci Rep. 6: 20154. PMID: 26821916
- Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status. | Durmaz, I., et al. 2016. Phytomedicine. 23: 42-51. PMID: 26902406
- Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells. | Chao, MW., et al. 2017. Sci Rep. 7: 46134. PMID: 28387249
- Lanatoside C inhibits cell proliferation and induces apoptosis through attenuating Wnt/β-catenin/c-Myc signaling pathway in human gastric cancer cell. | Hu, Y., et al. 2018. Biochem Pharmacol. 150: 280-292. PMID: 29475060
- Lanatoside C protects mice against bleomycin-induced pulmonary fibrosis through suppression of fibroblast proliferation and differentiation. | Nie, Y., et al. 2019. Clin Exp Pharmacol Physiol. 46: 575-586. PMID: 30854687
- Lanatoside C Induces G2/M Cell Cycle Arrest and Suppresses Cancer Cell Growth by Attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR Signaling Pathways. | Reddy, D., et al. 2019. Biomolecules. 9: PMID: 31783627
- Combination of 131I-trastuzumab and lanatoside C enhanced therapeutic efficacy in HER2 positive tumor model. | Vinod, N., et al. 2021. Sci Rep. 11: 12871. PMID: 34145369
- Lanatoside C inhibits human cervical cancer cell proliferation and induces cell apoptosis by a reduction of the JAK2/STAT6/SOCS2 signaling pathway. | Duan, Y., et al. 2021. Oncol Lett. 22: 740. PMID: 34466152
- Suppression of ER-stress induction of GRP78 as an anti-neoplastic mechanism of the cardiac glycoside Lanatoside C in pancreatic cancer: Lanatoside C suppresses GRP78 stress induction. | Ha, DP., et al. 2021. Neoplasia. 23: 1213-1226. PMID: 34768108
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lanatoside C, 10 mg | sc-211718 | 10 mg | $117.00 |