LAMP-5 Antibody (E-8): sc-398190

LAMP-5 Antibody (E-8) is a mouse monoclonal IgM antibody that detects LAMP-5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-LAMP-5 antibody (E-8) is available as the non-conjugated form. LAMP-5 protein, also known as C20orf103, is a 280 amino acid glycosylated type I membrane protein that plays a crucial role in lysosome biogenesis and is primarily located in neuronal cell body cytoplasmic vesicles. This localization suggests LAMP-5 may participate in protein trafficking and processing within neurons, which is essential for maintaining cellular homeostasis and function. LAMP-5 shows upregulation upon CpG activation and downregulation in response to Toll-like receptor ligands, indicating potential roles in immune responses and cellular signaling pathways. LAMP-5′s interactions with various lysosomal function proteins underscore its importance in cellular processes, making anti-LAMP-5 antibody (E-8) valuable for researchers studying lysosomal biology and related diseases.

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LAMP-5 Antibody (E-8) References:

1. Immune responses to T-cell epitopes of SARS CoV-N protein are enhanced by N immunization with a chimera of lysosome-associated membrane protein.  |  Yang, K., et al. 2009. Gene Ther. 16: 1353-62. PMID: 19727132
2. BAD-LAMP is a novel biomarker of nonactivated human plasmacytoid dendritic cells.  |  Defays, A., et al. 2011. Blood. 118: 609-17. PMID: 21642595
3. Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein.  |  Febbraio, M. and Silverstein, RL. 1990. J Biol Chem. 265: 18531-7. PMID: 2211717
4. Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx.  |  Wilke, S., et al. 2012. BMC Biol. 10: 62. PMID: 22809326
5. Induction of melanogenesis during the various melanoma growth phases and the role of tyrosinase, lysosome-associated membrane proteins, and p90 calnexin in the melanogenesis cascade.  |  Salopek, TG. and Jimbow, K. 1996. J Investig Dermatol Symp Proc. 1: 195-202. PMID: 9627716

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LAMP-5 Antibody (E-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-LAMP-5 Antibody (E-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LAMP-5 Antibody (E-8) Specifications

Alternate Product Name: LAMP-5

Product Clone Name: E-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 173-196

Epitope Target: LAMP-5

Epitope Species: human

Product Reactivity/Detection: LAMP-5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for LAMP-5 Antibody (E-8): P: Blocking Peptide