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Laminin-R Antibody (MLuC5) - Immunofluorescence - Image 142923
Laminin-R Antibody (MLuC5): sc-59732. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.
Laminin-R Antibody (MLuC5) - Immunofluorescence - Image 142923
Laminin-R Antibody (MLuC5): sc-59732. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.
Laminin-R Antibody (MLuC5) - Western Blotting - Image 129503
Laminin-R Antibody (MLuC5): sc-59732. Western blot analysis of Laminin-R expression in MCF7 (A) and PC-3 (B) whole cell lysates.
Laminin-R Antibody (MLuC5) - Western Blotting - Image 33114
Laminin-R Antibody (MLuC5): sc-59732. Western blot analysis of Laminin-R expression in non-transfected: sc-117752 (A) and human Laminin-R transfected: sc-116343 (B) 293T whole cell lysates.
Laminin-R Antibody (MLuC5): sc-59732. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

Laminin-R Antibody (MLuC5): sc-59732

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Datasheets
  • Laminin-R Antibody (MLuC5) is a mouse monoclonal IgM κ, cited in 11 publications, provided at 200 µg/ml
  • raised against live N592 small cell lung carcinoma cell line of human origin
  • recommended for detection of Laminin-R of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM
  • available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
  • See Laminin-R (H-2): sc-74515 for Laminin-R antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Laminin-R Antibody (MLuC5). This work is in progress.
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SEE ALSO...

Laminin-R Antibody (MLuC5) is a mouse monoclonal IgM antibody that detects Laminin-R in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Laminin-R, also known as colon carcinoma laminin-binding protein, plays a crucial role in cell adhesion and migration, which are essential processes in tissue development and repair, as well as in cancer metastasis. Laminin-R is characterized by its heterodimeric structure, which is similar to that of other extracellular matrix protein receptors, such as fibronectin and vitronectin. The incorporation of Laminin-R into lysosomal membranes facilitates the attachment of lysosomes to surfaces coated with laminin, highlighting Laminin-R′s importance in cellular interactions and signaling pathways. Notably, Laminin-R expression is significantly upregulated in aggressive carcinomas, particularly in colon cancer, where Laminin-R is found at nine-fold higher levels compared to adjacent normal colonic epithelium. This upregulation suggests that Laminin-R may serve as a potential biomarker for cancer progression and a target for therapeutic intervention. Additionally, the precursor of Laminin-R, identified as p40 ribosome-associated protein, is involved in the translational machinery, further underscoring Laminin-R′s multifunctional nature in cellular processes.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

Laminin-R Antibody (MLuC5) References:

  1. Carbohydrate-binding protein 35 is the major cell-surface laminin-binding protein in colon carcinoma.  |  Lee, EC., et al. 1991. Arch Surg. 126: 1498-502. PMID: 1842179
  2. Increased Expression of Laminin Subunit Alpha 1 Chain by dCas9-VP160.  |  Perrin, A., et al. 2017. Mol Ther Nucleic Acids. 6: 68-79. PMID: 28325301
  3. LABA/LAMA combinations versus LAMA monotherapy or LABA/ICS in COPD: a systematic review and meta-analysis.  |  Rodrigo, GJ., et al. 2017. Int J Chron Obstruct Pulmon Dis. 12: 907-922. PMID: 28360514
  4. LABA/LAMA fixed-dose combinations in patients with COPD: a systematic review.  |  Rogliani, P., et al. 2018. Int J Chron Obstruct Pulmon Dis. 13: 3115-3130. PMID: 30323582
  5. Single Inhaler LABA/LAMA for COPD.  |  Malerba, M., et al. 2019. Front Pharmacol. 10: 390. PMID: 31105560
  6. Comparing LAMA with LABA and LTRA as add-on therapies in primary care asthma management.  |  Kaplan, A., et al. 2020. NPJ Prim Care Respir Med. 30: 50. PMID: 33177503
  7. Long-acting muscarinic antagonist (LAMA) plus long-acting beta-agonist (LABA) versus LABA plus inhaled corticosteroid (ICS) for stable chronic obstructive pulmonary disease.  |  Fukuda, N., et al. 2023. Cochrane Database Syst Rev. 6: CD012066. PMID: 37276335
  8. Baseline Characteristics and ICS/LAMA/LABA Response in Asthma: Analyses From the CAPTAIN Study.  |  Boulet, LP., et al. 2024. J Allergy Clin Immunol Pract. 12: 1244-1253.e8. PMID: 38309696
  9. LAMA improves tissue oxygenation more than LABA in patients with COPD.  |  Perez-Bogerd, S., et al. 2024. J Appl Physiol (1985). 137: 154-165. PMID: 38722752
  10. Adding a LABA or LAMA to Current ICS Therapy for Uncontrolled Asthma.  |  Fletke, KJ. and Trasybule, N. 2024. Am Fam Physician. 110: 346-347. PMID: 39418565

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Laminin-R Antibody (MLuC5)

sc-59732
200 µg/ml
$322.00

Laminin-R Antibody (MLuC5) FITC

sc-59732 FITC
200 µg/ml
$336.00

Laminin-R Antibody (MLuC5) PE

sc-59732 PE
200 µg/ml
$349.00

Hello, Is there azide or other type of preservative mixed with MLuC5 (sc-59732)? Thanks.

Asked by: Rutdol
Thank you for your question. Yes, each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
Answered by: Tech Service
Date published: 2020-03-04

Can Laminin-R (MLuC5): sc-59732 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: DefinitelyNotMatt
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Laminin-R (MLuC5): sc-59732 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from High Quality ProductThe Laminin-R Antibody (MLuC5): sc-59732 works very well for immunofluorescence applications showing staining pattern with membrane localization.
Date published: 2017-02-09
Rated 5 out of 5 by from using antibdoy blockinglaminin r antibody 5μg/ml in macrophage have good result.
Date published: 2016-11-20
Rated 4 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB. -SCBT QC
Date published: 2015-05-14
Rated 4 out of 5 by from Produced robust immunofluorescence membraneProduced robust immunofluorescence membrane staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-04-02
Rated 4 out of 5 by from Bands seen in WB using MCF7 and PCBands seen in WB using MCF7 and PC-3 whole cell lysates. -SCBT QC
Date published: 2015-01-03
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Laminin-R Antibody (MLuC5) is rated 4.4 out of 5 by 5.
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