Laminin γ-1 Antibody (A5): sc-33708

Laminin γ-1 Antibody (A5) is a rat monoclonal IgG2a antibody that detects Laminin γ-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Laminin γ-1 plays a crucial role in the formation and maintenance of basement membranes, which are specialized extracellular matrices that provide structural support to tissues and influence various cellular processes. These membranes are essential for tissue integrity and function, as they regulate cell proliferation, migration, and differentiation. Laminin γ-1 is a heterotrimer composed of alpha, beta, and gamma chain subunits, which allows for self-assembly and interaction with other matrix components, such as Type IV collagen and proteoglycans. This unique structure is vital for the stability and functionality of the basement membrane, as Laminin γ-1 facilitates interactions with cell surface receptors like integrins and dystroglycan, thereby influencing cellular behavior and tissue architecture. Laminin γ-1 is encoded by a gene located on chromosome 1q31 and is widely expressed in various tissues, underscoring its importance in both normal physiology and potential pathological conditions. Anti-Laminin γ-1 antibody (A5) is an invaluable tool for researchers studying the dynamics of basement membranes and their impact on cellular functions.

The preferred Laminin γ-1 antibody is Laminin γ-1 Antibody (B-4): sc-13144.