Laminin β-1/γ-1 Antibody (612C10): sc-47766
- Laminin β-1/γ-1 Antibody (612C10) is a mouse monoclonal IgG1 Laminin β-1/γ-1 antibody provided at 200 µg/ml
- raised against purified placental Laminin β-1/γ-1 complex complex of human origin
- recommended for detection of Laminin β-1/γ-1 complex of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Laminin β-1/γ-1 Antibody (612C10). This work is in progress.
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Laminin β-1/γ-1 Antibody (612C10) is a mouse monoclonal IgG1 antibody that detects Laminin β-1/γ-1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Laminin β-1/γ-1 antibody (612C10) is available as a non-conjugated format. Laminins, including Laminin β-1 and γ-1 chains, play a crucial role in forming and maintaining basement membranes, which are specialized extracellular matrices providing structural support to tissues. These basement membranes are essential for tissue integrity and influence cellular processes like proliferation, migration, and differentiation. The unique structure of laminins, consisting of heterotrimeric assemblies of α, β, and γ chains, allows interaction with various cell surface receptors, including integrins and dystroglycan, facilitating cell adhesion and signaling. Proper functioning of laminins is vital for tissue development and repair, as well as maintaining organ architecture. Human Laminin β-1 gene is located on chromosome 7q22, while Laminin γ-1 gene is found on chromosome 1q31, with both genes being widely expressed in tissues that produce basement membranes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Laminin β-1/γ-1 Antibody (612C10) References:
- bcn-1 Element-dependent activation of the laminin gamma 1 chain gene by the cooperative action of transcription factor E3 (TFE3) and Smad proteins. | Kawata, Y., et al. 2002. J Biol Chem. 277: 11375-84. PMID: 11801598
- Entactin and laminin gamma 1-chain gene expression in the early chick embryo. | Zagris, N., et al. 2005. Int J Dev Biol. 49: 65-70. PMID: 15744670
- Laminin/β1 integrin signal triggers axon formation by promoting microtubule assembly and stabilization. | Lei, WL., et al. 2012. Cell Res. 22: 954-72. PMID: 22430151
- Analysis of nidogen-1/laminin γ1 interaction by cross-linking, mass spectrometry, and computational modeling reveals multiple binding modes. | Lössl, P., et al. 2014. PLoS One. 9: e112886. PMID: 25387007
- Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions-Brief Report. | Wagner, JUG., et al. 2018. Arterioscler Thromb Vasc Biol. 38: 1170-1177. PMID: 29599141
- The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells. | Villanueva, AA., et al. 2019. Cell Adh Migr. 13: 33-40. PMID: 30160193
- The Adult Murine Intestine is Dependent on Constitutive Laminin-γ1 Synthesis. | Fields, B., et al. 2019. Sci Rep. 9: 19303. PMID: 31848396
- Integrin subunit β1 and laminin γ1 chain expression: a potential prognostic biomarker in cervical cancer. | Zacapala-Gómez, AE., et al. 2020. Biomark Med. 14: 1461-1471. PMID: 32845182
- Extracellular matrix protein laminin β1 regulates pain sensitivity and anxiodepression-like behaviors in mice. | Li, ZZ., et al. 2021. J Clin Invest. 131: PMID: 34156983
- Oligodendrocyte-derived laminin-γ1 regulates the blood-brain barrier and CNS myelination in mice. | Kang, M. and Yao, Y. 2024. Cell Rep. 43: 114123. PMID: 38635399
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Laminin β-1/γ-1 Antibody (612C10) | sc-47766 | 200 µg/ml | $316.00 |