Laforin Antibody (k2A3): sc-135810

Laforin Antibody (k2A3) is a mouse monoclonal IgG1 antibody that detects the Laforin protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Laforin antibody (k2A3) is available as a non-conjugated format. Laforin, also known as Lafora PTPase, is a dual specificity protein phosphatase that plays a crucial role in glycogen metabolism, particularly in the regulation and prevention of poorly branched glycogen molecules, which are associated with various metabolic disorders. Laforin is predominantly expressed in heart, skeletal muscle, kidney, pancreas, and brain tissues, highlighting its importance in maintaining cellular energy homeostasis. Laforin contains one carbohydrate binding type-20 domain and one tyrosine-protein phosphatase domain, which are essential for enzymatic activity and substrate specificity. Notably, Laforin isoform 1 is primarily localized to polyribosomes at the endoplasmic reticulum, while isoform 2 is found in the nucleus, indicating diverse functional roles within the cell. Defects in the EPM2A gene, which encodes Laforin, are linked to progressive myoclonic epilepsy type 2 (EPM2), also known as Lafora disease, a severe autosomal recessive disorder characterized by adolescent-onset epilepsy and neurodegeneration. Laforin monoclonal antibody (k2A3) effectively detects this critical protein, making anti-Laforin antibody (k2A3) a valuable tool for research into glycogen storage diseases and related neurological conditions.

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Laforin Antibody (k2A3) References:

1. Laforin, defective in the progressive myoclonus epilepsy of Lafora type, is a dual-specificity phosphatase associated with polyribosomes.  |  Ganesh, S., et al. 2000. Hum Mol Genet. 9: 2251-61. PMID: 11001928
2. Mutation screening for Japanese Lafora's disease patients: identification of novel sequence variants in the coding and upstream regulatory regions of EPM2A gene.  |  Ganesh, S., et al. 2001. Mol Cell Probes. 15: 281-9. PMID: 11735300
3. A unique carbohydrate binding domain targets the lafora disease phosphatase to glycogen.  |  Wang, J., et al. 2002. J Biol Chem. 277: 2377-80. PMID: 11739371
4. Alternative splicing modulates subcellular localization of laforin.  |  Ganesh, S., et al. 2002. Biochem Biophys Res Commun. 291: 1134-7. PMID: 11883934
5. Genotype-phenotype correlations for EPM2A mutations in Lafora's progressive myoclonus epilepsy: exon 1 mutations associate with an early-onset cognitive deficit subphenotype.  |  Ganesh, S., et al. 2002. Hum Mol Genet. 11: 1263-71. PMID: 12019207
6. Two novel mutations in the EPM2A gene in a Korean patient with Lafora's progressive myoclonus epilepsy.  |  Ki, CS., et al. 2003. J Hum Genet. 48: 51-4. PMID: 12560877
7. Identification of a novel protein interacting with laforin, the EPM2a progressive myoclonus epilepsy gene product.  |  Ianzano, L., et al. 2003. Genomics. 81: 579-87. PMID: 12782127
8. The Lafora disease gene product laforin interacts with HIRIP5, a phylogenetically conserved protein containing a NifU-like domain.  |  Ganesh, S., et al. 2003. Hum Mol Genet. 12: 2359-68. PMID: 12915448
9. Molecular characterization of laforin, a dual-specificity protein phosphatase implicated in Lafora disease.  |  Girard, JM., et al. 2006. Biochimie. 88: 1961-71. PMID: 17010495

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Laforin Antibody (k2A3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Laforin Antibody (k2A3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Laforin Antibody (k2A3) Specifications

Alternate Product Name: Laforin

Product Clone Name: k2A3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 243-331

Epitope Target: Laforin

Epitope Species: human

Product Reactivity/Detection: Laforin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Laforin Antibody (k2A3): N/A