Molecular structure of Lacto-N-fucopentaose III, CAS Number: 25541-09-7
Lacto-N-fucopentaose III (CAS 25541-09-7)
Alternate Names:
Lewis-X pentasaccharide; β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-D-Glc
Application:
Lacto-N-fucopentaose III is a polysaccharide used for proteomics research
CAS Number:
25541-09-7
Molecular Weight:
853.77
Molecular Formula:
C32H55NO25
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Lacto-N-fucopentaose III (LNFP III) is a polysaccharide used for proteomics research. It can also be used as a substrate to promote the growth of beneficial gut bacteria. Lacto-N-fucopentaose III is utilized in glycobiology research to study the interactions between carbohydrates and proteins. It can be used as a reference standard for the detection and quantification of fucosylated carbohydrates. It also serves as a building block for the synthesis of more complex oligosaccharides or glycans. Additionally, Lacto-N-fucopentaose III has immunomodulatory and anti-inflammatory properties.
Lacto-N-fucopentaose III (CAS 25541-09-7) References
- Lacto-N-fucopentaose III found on Schistosoma mansoni egg antigens functions as adjuvant for proteins by inducing Th2-type response. | Okano, M., et al. 2001. J Immunol. 167: 442-50. PMID: 11418681
- Pre-clinical evaluation of anti-lacto-N-fucopentaose III (CD15) monoclonal antibodies for ex vivo bone marrow purging in acute myeloid leukemia. | Guyotat, D., et al. 1990. Bone Marrow Transplant. 6: 385-90. PMID: 1982926
- Lacto-N-fucopentaose III, a pentasaccharide, prolongs heart transplant survival. | Dutta, P., et al. 2010. Transplantation. 90: 1071-8. PMID: 20885339
- Immune modulation by Lacto-N-fucopentaose III in experimental autoimmune encephalomyelitis. | Zhu, B., et al. 2012. Clin Immunol. 142: 351-61. PMID: 22264636
- Synthesis of the Tolerance-Inducing Oligosaccharide Lacto-N-Fucopentaose III Bearing an Activated Linker. | Zhang, J., et al. 2013. ChemistryOpen. 2: 156-63. PMID: 24551556
- Immunomodulatory glycan lacto-N-fucopentaose III requires clathrin-mediated endocytosis to induce alternative activation of antigen-presenting cells. | Srivastava, L., et al. 2014. Infect Immun. 82: 1891-903. PMID: 24566617
- Efficient production of lacto-N-fucopentaose III in engineered Escherichia coli using α1,3-fucosyltransferase from Parabacteroides goldsteinii. | Sugita, T., et al. 2023. J Biotechnol. 361: 110-118. PMID: 36509384
- Lacto-N-fucopentaose III activity in the serum of patients with ovarian carcinoma. | Cox, CJ., et al. 1986. Gynecol Obstet Invest. 21: 164-8. PMID: 3710289
- My-1, the human myeloid-specific antigen detected by mouse monoclonal antibodies, is a sugar sequence found in lacto-N-fucopentaose III. | Huang, LC., et al. 1983. Blood. 61: 1020-3. PMID: 6187397
- Immunohistochemical localization of the immunodominant differentiation antigen lacto-N-fucopentaose III in normal adult and fetal tissues. | Combs, SG., et al. 1984. J Histochem Cytochem. 32: 982-8. PMID: 6379043
- Monoclonal antibodies PMN 6, PMN 29, and PM-81 bind differently to glycolipids containing a sugar sequence occurring in lacto-N-fucopentaose III. | Magnani, JL., et al. 1984. Arch Biochem Biophys. 233: 501-6. PMID: 6486796
- A multivalent lacto-N-fucopentaose III-lysyllysine conjugate decompacts preimplantation mouse embryos, while the free oligosaccharide is ineffective. | Fenderson, BA., et al. 1984. J Exp Med. 160: 1591-6. PMID: 6491606
- Many monoclonal antibodies with an apparent specificity for certain lung cancers are directed against a sugar sequence found in lacto-N-fucopentaose III. | Huang, LC., et al. 1983. Arch Biochem Biophys. 220: 318-20. PMID: 6830241
- Expression of lacto-N-fucopentaose III (CD15)- and sialyl-Lewis X-bearing molecules and their functional properties in eosinophils from patients with the idiopathic hypereosinophilic syndrome. | Satoh, T., et al. 1994. Immunology. 83: 313-8. PMID: 7835953
- Lacto-N-fucopentaose III (Lewis x), a target of the antibody response in mice vaccinated with irradiated cercariae of Schistosoma mansoni. | Richter, D., et al. 1996. Infect Immun. 64: 1826-31. PMID: 8613397
Inhibitor of:
FucT-IV.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lacto-N-fucopentaose III, 1 mg | sc-257658 | 1 mg | $1243.00 |