La/SSB Antibody (44): sc-136258

La/SSB Antibody (44) is a mouse monoclonal IgG1 antibody that detects La/SSB in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). La/SSB is an autoimmune RNA-binding protein that plays a crucial role in the transcription of RNA polymerase III, which is essential for synthesizing various small RNAs, including tRNA and 5S rRNA. The proper functioning of La/SSB is vital for maintaining cellular homeostasis and regulating gene expression, as disruptions in La/SSB activity can lead to autoimmune diseases such as Sjögren syndrome and systemic lupus erythematosus. La/SSB interacts with several other proteins, including the Ro/SSA ribonucleoprotein complex, which is significant because autoantibodies against La/SSB and Ro/SSA are commonly observed in patients with these autoimmune conditions. The genes encoding La/SSB and Ro/SSA are located on human chromosomes 1q31 and 11p15.5, respectively, highlighting their genetic linkage and potential co-regulation in immune responses. Anti-La/SSB antibody (44) is an invaluable tool for researchers studying the molecular mechanisms underlying autoimmune diseases and the role of RNA-binding proteins in cellular processes.

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La/SSB Antibody (44) References:

1. Ro/SSA and La/SSB specific IgA autoantibodies in serum of patients with Sjögren's syndrome and systemic lupus erythematosus.  |  Pourmand, N., et al. 1999. Ann Rheum Dis. 58: 623-9. PMID: 10491361
2. Subcellular redistribution of la/SSB autoantigen during physiologic apoptosis in the fetal mouse heart and conduction system: a clue to the pathogenesis of congenital heart block.  |  Tran, HB., et al. 2002. Arthritis Rheum. 46: 202-8. PMID: 11817591
3. Autoantibodies to dsDNA, Ro/SSA, and La/SSB in systemic lupus erythematosus.  |  Chien, JW. and Lin, CY. 2003. Adv Clin Chem. 37: 129-72. PMID: 12619707
4. A complementary La/SSB epitope anchored to Sequential Oligopeptide Carrier regulates the anti-La/SSB response in immunized animals.  |  Voitharou, C., et al. 2008. J Pept Sci. 14: 1069-76. PMID: 18618423
5. The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: another angle of the autoimmune mosaic.  |  Agmon-Levin, N., et al. 2017. Clin Exp Rheumatol. 35: 929-935. PMID: 28770708
6. Increased risk of multiple myeloma in primary Sjögren's syndrome is limited to individuals with Ro/SSA and La/SSB autoantibodies.  |  Mofors, J., et al. 2020. Ann Rheum Dis. 79: 307-308. PMID: 31694814
7. Natural killer cells and type II interferon in Ro/SSA and La/SSB autoantibody-exposed newborns at risk of congenital heart block.  |  Ivanchenko, M., et al. 2021. Ann Rheum Dis. 80: 194-202. PMID: 33004330
8. Evaluation of recombinant Ro/SSA, La/SSB, Sm, and U1 RNP autoantigens in clinical diagnosis.  |  García Lerma, JG., et al. 1995. J Clin Lab Anal. 9: 52-8. PMID: 7722773
9. Subclass distribution of maternal and neonatal anti-Ro(SSA) and La(SSB) antibodies in congenital heart block.  |  Tseng, CE., et al. 1996. J Rheumatol. 23: 925-32. PMID: 8724310
10. Autoantibodies reactive with Ro(SSA) and La(SSB) and pregnancy.  |  Buyon, JP. 1997. J Rheumatol Suppl. 50: 12-6. PMID: 9292829

The preferred La/SSB antibody is La/SSB Antibody (312B): sc-80656.