L428 Cell Lysate: sc-24728

L428 cell lysate is derived from the L428 cell line, which is a model for Hodgkin's lymphoma, used extensively in hematological research to study the molecular biology of this disease. This lysate provides a valuable tool for examining the signaling pathways and gene expression profiles specific to Hodgkin's lymphoma. Researchers use L428 lysate to investigate the role of nuclear factor kappa B (NF-κB), a key transcription factor that is constitutively active in many cases of Hodgkin's lymphoma and drives the expression of genes involved in cell proliferation and survival. Additionally, the lysate is employed to study the interactions between the malignant cells and their microenvironment, particularly focusing on cytokines and chemokines that support tumor growth and evade immune surveillance. Studies utilizing L428 cell lysate also explore the expression of surface markers like CD30 and CD15, which are characteristic of Reed-Sternberg cells, providing insights into cell differentiation and the pathogenesis of Hodgkin's lymphoma. These investigations, carried out exclusively in a research context, aim to uncover fundamental insights into the biology of Hodgkin's lymphoma, aiding in the development of targeted research tools and methodologies.

L428 Cell Lysate References:

1. Expression of human DEC-205 (CD205) multilectin receptor on leukocytes.  |  Kato, M., et al. 2006. Int Immunol. 18: 857-69. PMID: 16581822
2. A pro-inflammatory role for nuclear factor kappa B in childhood obstructive sleep apnea syndrome.  |  Israel, LP., et al. 2013. Sleep. 36: 1947-55. PMID: 24293770
3. Establishment of a Therapeutic Anti-Pan HLA-Class II Monoclonal Antibody That Directly Induces Lymphoma Cell Death via Large Pore Formation.  |  Matsuoka, S., et al. 2016. PLoS One. 11: e0150496. PMID: 27028595