L-xylulose reductase Antibody (18-Q): sc-100552

L-xylulose reductase Antibody (18-Q) is a mouse monoclonal IgG1 kappa light chain antibody that detects L-xylulose reductase of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-L-xylulose reductase antibody (18-Q) is available as the non-conjugated monoclonal isotype antibody. L-xylulose reductase (XR), also known as kidney dicarbonyl reductase (kiDCR) or sperm surface protein P34H, is a 244 amino acid protein belonging to the short-chain dehydrogenases/reductases family. This enzyme plays a crucial role in the renal tubules by catalyzing the NADPH-dependent reduction of various sugars, including L-xylulose, to the osmolyte xylitol, which is vital for preventing osmotic stress in kidney cells. L-xylulose reductase functions as a homotetramer to enhance enzymatic efficiency and is predominantly expressed in the kidney, liver, and epididymis. A partial deficiency in L-xylulose reductase can lead to essential pentosuria, characterized by the presence of L-xylulose in the urine. Normal red blood cells contain two isozymes of L-xylulose reductase, while those from patients with pentosuria exhibit only one isozyme. Given L-xylulose reductase′s involvement in the uronate cycle of glucose metabolism, this enzyme has been implicated in managing long-term complications associated with diabetes, making L-xylulose reductase a significant target for research and therapeutic interventions.

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L-xylulose reductase Antibody (18-Q) References:

1. Identification of amino acid residues involved in substrate recognition of L-xylulose reductase by site-directed mutagenesis.  |  Ishikura, S., et al. 2003. Chem Biol Interact. 143-144: 543-50. PMID: 12604240
2. Structural determinant for cold inactivation of rodent L-xylulose reductase.  |  Ishikura, S., et al. 2003. Biochem Biophys Res Commun. 308: 68-72. PMID: 12890481
3. Different clinical and morphological phenotypes in monozygotic twins with identical DCX mutation.  |  Martin, P., et al. 2004. J Neurol. 251: 108-10. PMID: 14999500
4. Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis.  |  El-Kabbani, O., et al. 2004. Proteins. 55: 724-32. PMID: 15103634
5. P26h and dicarbonyl/L-xylulose reductase are two distinct proteins present in the hamster epididymis.  |  St-Cyr, A., et al. 2004. Mol Reprod Dev. 69: 137-45. PMID: 15293214
6. Structure of the tetrameric form of human L-Xylulose reductase: probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis.  |  El-Kabbani, O., et al. 2005. Proteins. 60: 424-32. PMID: 15906319
7. Suppression of AGE precursor formation following unilateral ureteral obstruction in mouse kidneys by transgenic expression of alpha-dicarbonyl/L-xylulose reductase.  |  Asami, J., et al. 2006. Biosci Biotechnol Biochem. 70: 2899-905. PMID: 17151462
8. On the nature of L-xylulose reductase deficiency in essential pentosuria.  |  Lane, AB. 1985. Biochem Genet. 23: 61-72. PMID: 3994659
9. Structure-based discovery of human L-xylulose reductase inhibitors from database screening and molecular docking.  |  Carbone, V., et al. 2005. Bioorg Med Chem. 13: 301-12. PMID: 15598553

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-L-xylulose reductase Antibody (18-Q) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-L-xylulose reductase Antibody (18-Q) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

L-xylulose reductase Antibody (18-Q) Specifications

Alternate Product Name: L-xylulose reductase

Product Clone Name: 18-Q

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 145-245

Epitope Target: L-xylulose reductase

Epitope Species: human

Product Reactivity/Detection: L-xylulose reductase

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for L-xylulose reductase Antibody (18-Q): N/A