L-trans-Pyrrolidine-2,4-dicarboxylic acid (CAS 64769-66-0)
See product citations (8)
QUICK LINKS
L-trans-Pyrrolidine-2,4-dicarboxylic acid (L-trans-PDC) is a glutamate uptake blocker, serving as a "conformer mimic" of the glutamate molecule as recognized by EAAT (excitatory amino acid transporter) proteins. L-trans-Pyrrolidine-2,4-dicarboxylic acid is demonstrated to increase extracellular glutamate concentration without affecting extracellular GABA levels. Blockade of glutamate uptake by L-trans-Pyrrolidine-2,4-dicarboxylic acid has a correlated effect of inducing neuronal Ca2+ influx and massive NMDA receptor-mediated neuronal death. Specificity of L-trans-Pyrrolidine-2,4-dicarboxylic acid for the EAAT protein over other glutamate-recognizing loci indicates a particular structural requirement for the EAAT binding site, satisfied by this structurally rigid pyrrolidine "conformer mimic" of glutamate. L-trans-Pyrrolidine-2,4-dicarboxylic acid is an inhibitor of EAAT1, EAAT2, EAAT3, EAAT4 and EAAT5.
L-trans-Pyrrolidine-2,4-dicarboxylic acid (CAS 64769-66-0) References
- Effects of high-potassium-induced depolarization on amino acid chemistry of the dorsal cochlear nucleus in rat brain slices. | Zheng, L., et al. 2000. Neurochem Res. 25: 823-35. PMID: 10944001
- Proline-glutamate chimeras in isopeptides. Synthesis and biological evaluation of conformationally restricted glutathione analogues. | Paradisi, MP., et al. 2003. Bioorg Med Chem. 11: 1677-83. PMID: 12659754
- Na(+)-dependent high-affinity uptake of L-glutamate in cultured fibroblasts. | Balcar, VJ. 1992. FEBS Lett. 300: 203-7. PMID: 1348229
- Brain excitatory amino acid transporters (EAATs) and treatment of methamphetamine toxicity. | Hayase, T., et al. 2003. Nihon Arukoru Yakubutsu Igakkai Zasshi. 38: 498-511. PMID: 14750360
- Inhibition of glutamate uptake in the spinal cord induces hyperalgesia and increased responses of spinal dorsal horn neurons to peripheral afferent stimulation. | Weng, HR., et al. 2006. Neuroscience. 138: 1351-60. PMID: 16426766
- Effects of theanine, r-glutamylethylamide, on neurotransmitter release and its relationship with glutamic acid neurotransmission. | Yamada, T., et al. 2005. Nutr Neurosci. 8: 219-26. PMID: 16493792
- Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer. | Bridges, RJ., et al. 1991. J Med Chem. 34: 717-25. PMID: 1671706
- Reverse glial glutamate uptake triggers neuronal cell death through extrasynaptic NMDA receptor activation. | Gouix, E., et al. 2009. Mol Cell Neurosci. 40: 463-73. PMID: 19340933
- Tunicamycin produces TDP-43 cytoplasmic inclusions in cultured brain organotypic slices. | Leggett, C., et al. 2012. J Neurol Sci. 317: 66-73. PMID: 22459357
- The uptake inhibitor L-trans-PDC enhances responses to glutamate but fails to alter the kinetics of excitatory synaptic currents in the hippocampus. | Isaacson, JS. and Nicoll, RA. 1993. J Neurophysiol. 70: 2187-91. PMID: 7905032
- Enhancement of 3[H]D-aspartate release during ischemia like conditions in rat hippocampal slices: source of excitatory amino acids. | Zabłocka, B. and Domańska-Janik, K. 1996. Acta Neurobiol Exp (Wars). 56: 63-70. PMID: 8787212
- Effects of uptake carrier blockers SK & F 89976-A and L-trans-PDC on in vivo release of amino acids in rat hippocampus. | Zuiderwijk, M., et al. 1996. Eur J Pharmacol. 307: 275-82. PMID: 8836615
- A high affinity glutamate/aspartate transport system in pancreatic islets of Langerhans modulates glucose-stimulated insulin secretion. | Weaver, CD., et al. 1998. J Biol Chem. 273: 1647-53. PMID: 9430708
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-trans-Pyrrolidine-2,4-dicarboxylic acid, 5 mg | sc-200477 | 5 mg | $66.00 | |||
L-trans-Pyrrolidine-2,4-dicarboxylic acid, 25 mg | sc-200477A | 25 mg | $419.00 |