Molecular structure of L-thiocitrulline, Dihydrochloride, CAS Number: 212051-53-1
L-thiocitrulline, Dihydrochloride (CAS 212051-53-1)
Application:
L-thiocitrulline, Dihydrochloride is an inhibitor of NOS1, NOS2, and NOS3
CAS Number:
212051-53-1
Purity:
≥95%
Molecular Weight:
264.20
Molecular Formula:
C6H13N3O2S•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-thiocitrulline, Dihydrochloride is a potent stereospecific inhibitor of all three isoforms of rat NOS (NOS1, NOS2, and NOS3), that has greater inhibitory activity on NOS1 (nNOS) (Ki = 60 nM), compared to NOS2 (iNOS) (Ki = 3.6 μM). L-thiocitrulline inhibition is competitive with respect to L-Arginine, a native substrate, which suggests that L-thiocitrulline preferentially occupies the L-Arginine binding site.
L-thiocitrulline, Dihydrochloride (CAS 212051-53-1) References
- Nitric oxide synthase inhibition delays axonal degeneration and promotes the survival of axotomized retinal ganglion cells. | Koeberle, PD. and Ball, AK. 1999. Exp Neurol. 158: 366-81. PMID: 10415143
- Synthesis of L-thiocitrulline, L-homothiocitrulline, and S-methyl-L-thiocitrulline: a new class of potent nitric oxide synthase inhibitors. | Narayanan, K. and Griffith, OW. 1994. J Med Chem. 37: 885-7. PMID: 7512141
- L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. | Frey, C., et al. 1994. J Biol Chem. 269: 26083-91. PMID: 7523401
Inhibitor of:
Enzyme, NOS1, NOS2, and NOS3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-thiocitrulline, Dihydrochloride, 10 mg | sc-3572 | 10 mg | $62.00 | |||
L-thiocitrulline, Dihydrochloride, 50 mg | sc-3572A | 50 mg | $245.00 |