Molecular structure of L-Sepiapterin, CAS Number: 17094-01-8
L-Sepiapterin (CAS 17094-01-8)
See product citations (3)
Alternate Names:
2-Amino-6-(S)-lactoyl-7,8-dihydro-4(3H)-pteridinone
Application:
An intermediate in the salvage pathway of tetrahydrobiopterin
CAS Number:
17094-01-8
Molecular Weight:
237.22
Molecular Formula:
C9H11N5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
L-Sepiapterin is a naturally occurring compound that plays a role in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for the synthesis of neurotransmitters and the regulation of nitric oxide production. In research applications, L-Sepiapterin is utilized to study the enzymatic pathways involved in BH4 synthesis and regeneration. It is particularly useful in examining the function and activity of sepiapterin reductase, the enzyme responsible for the final step in BH4 biosynthesis. Researchers also employ L-Sepiapterin in studies focused on understanding the etiology of diseases associated with BH4 deficiencies, such as certain forms of phenylketonuria and dihydropteridine reductase deficiency. Additionally, this compound is used in experiments designed to assess the impact of BH4 on endothelial function and oxidative stress.
L-Sepiapterin (CAS 17094-01-8) References
- Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin. | Gramsbergen, JB., et al. 2002. Brain Res. 935: 47-58. PMID: 12062472
- Tetrahydrobiopterin precursor sepiapterin provides protection against neurotoxicity of 1-methyl-4-phenylpyridinium in nigral slice cultures. | Madsen, JT., et al. 2003. J Neurochem. 85: 214-23. PMID: 12641743
- Pterins inhibit nitric oxide synthase activity in rat alveolar macrophages. | Jorens, PG., et al. 1992. Br J Pharmacol. 107: 1088-91. PMID: 1281717
- Tetrahydrobiopterin rapidly reduces the SOD mimic Mn(III) ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrin. | Batinić-Haberle, I., et al. 2004. Free Radic Biol Med. 37: 367-74. PMID: 15223070
- D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum Ax2. | Choi, YK., et al. 2005. FEBS Lett. 579: 3085-9. PMID: 15896778
- DAF-FM (4-amino-5-methylamino-2',7'-difluorofluorescein) diacetate detects impairment of agonist-stimulated nitric oxide synthesis by elevated glucose in human vascular endothelial cells: reversal by vitamin C and L-sepiapterin. | Sheng, JZ., et al. 2005. J Pharmacol Exp Ther. 315: 931-40. PMID: 16093274
- Mechanisms of H2O2-induced oxidative stress in endothelial cells. | Coyle, CH., et al. 2006. Free Radic Biol Med. 40: 2206-13. PMID: 16785034
- A tunable FRET circuit for engineering fluorescent biosensors. | Allen, MD. and Zhang, J. 2008. Angew Chem Int Ed Engl. 47: 500-2. PMID: 18058965
- Certain progestins prevent the enhancing effect of 17beta-estradiol on NO-mediated inhibition of platelet aggregation by endothelial cells. | Zerr-Fouineau, M., et al. 2009. Arterioscler Thromb Vasc Biol. 29: 586-93. PMID: 19096000
- Endothelial nitric oxide synthase uncoupling as a key mediator of melanocyte malignant transformation associated with sustained stress conditions. | Melo, FH., et al. 2011. Free Radic Biol Med. 50: 1263-73. PMID: 21362470
- Capillary electrophoresis of pterin derivatives responsible for the warning coloration of Heteroptera. | Krajíček, J., et al. 2014. J Chromatogr A. 1336: 94-100. PMID: 24602308
- Berberine suppresses the ectopic expression of miR-133a in endothelial cells to improve vascular dementia in diabetic rats. | Yin, S., et al. 2019. Clin Exp Hypertens. 41: 708-716. PMID: 30472896
- L-sepiapterin restores SLE serum-induced markers of endothelial function in endothelial cells. | Jones Buie, JN., et al. 2019. Lupus Sci Med. 6: e000294. PMID: 31168396
- Metastatic Melanoma Progression Is Associated with Endothelial Nitric Oxide Synthase Uncoupling Induced by Loss of eNOS:BH4 Stoichiometry. | Melo, FHM., et al. 2021. Int J Mol Sci. 22: PMID: 34502464
- Superoxide production, risk factors, and endothelium-dependent relaxations in human internal mammary arteries. | Huraux, C., et al. Circulation. 99: 53-9. PMID: 9884379
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Sepiapterin, 500 µg | sc-506156D | 500 µg | $550.00 | |||
L-Sepiapterin, 1 mg | sc-506156 | 1 mg | $1000.00 | |||
L-Sepiapterin, 2 mg | sc-506156A | 2 mg | $1800.00 | |||
L-Sepiapterin, 3 mg | sc-506156B | 3 mg | $2500.00 | |||
L-Sepiapterin, 5 mg | sc-506156C | 5 mg | $3400.00 |