Molecular structure of L-Selenomethionine, CAS Number: 3211-76-5
L-Selenomethionine (CAS 3211-76-5)
See product citations (1)
Alternate Names:
SeMet L-selenomethionine L-(+)-Selenomethionine Seleno-L-methionine Selenium-L-methionine (S)-2-Amino-4-(methylselanyl)butanoic acid L-Selenomethioninum (S)-2-Amino-4-(methylseleno)butyric acid (S)-2-Amino-4-(methylseleno)butanoic acid
Application:
L-Selenomethionine is a compound shown to increase expression of glutathione peroxidase
CAS Number:
3211-76-5
Purity:
≥98%
Molecular Weight:
196.1
Molecular Formula:
C5H11NO2Se
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
L-Selenomethionine displays antioxidant activity and may act to increase the activity of glutathione peroxidase in endothelial cells. Glutathione peroxidase protects cells from oxidative damage, such as DNA strand breaks, mutations and interference with protein tyrosine-based signaling and other protein functions due to formation of 3-nitrotyrosine, caused by excessive peroxynitrite. L-Selenomethionine administration to cancer cell lines (MCF-7/S breast carcinoma, DU-145 prostate cancer cells and UACC-375 melanoma) results in apoptotic cell death and aberrant mitosis. These human tumor cell lines exhibited dose-dependent growth inhibition by L-Selenomethionine in the micromolar range (45 to 130 muM), while growth inhibition of normal fibroblasts required 1 mM L-Selenomethionine.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
L-Selenomethionine (CAS 3211-76-5) References
- Selenium metabolites in human urine after ingestion of selenite, L-selenomethionine, or DL-selenomethionine: a quantitative case study by HPLC/ICPMS. | Kuehnelt, D., et al. 2005. Anal Bioanal Chem. 383: 235-46. PMID: 16132136
- Synthesis of D- and L-selenomethionine double-labeled with deuterium and selenium-82. | Matsukawa, T., et al. 2010. Chem Pharm Bull (Tokyo). 58: 1658-60. PMID: 21139275
- L-selenomethionine does not protect against testosterone plus 17β-estradiol-induced oxidative stress and preneoplastic lesions in the prostate of NBL rats. | Özten, N., et al. 2014. Nutr Cancer. 66: 825-34. PMID: 24773027
- Electrochemical Oxidation of l-selenomethionine and Se-methylseleno-l-cysteine at a Thiol-Compound-Modified Gold Electrode: Its Application in a Flow-Through Voltammetric Sensor. | Wang, LH. and Zhang, YH. 2017. Sensors (Basel). 17: PMID: 28212326
- Toxicity of Aqueous L-Selenomethionine and Tert-Butyl Hydroperoxide Exposure to Zebrafish (Danio rerio) Embryos Following Tert-Butyl Hydroquinone Treatment. | Gerhart, AK. and Janz, DM. 2019. Toxics. 7: PMID: 31470549
- l-selenomethionine induces zebrafish embryo cardiovascular defects via down-regulating expression of lrp2b. | Zhao, G., et al. 2022. Chemosphere. 290: 133351. PMID: 34933029
- Evaluation of L-Selenomethionine on Ameliorating Cardiac Injury Induced by Environmental Ammonia. | Zhang, X., et al. 2022. Biol Trace Elem Res. 200: 4712-4725. PMID: 35094233
- Evaluation of potential cardiotoxicity of ammonia: l-selenomethionine inhibits ammonia-induced cardiac autophagy by activating the PI3K/AKT/mTOR signaling pathway. | Cheng, Z., et al. 2022. Ecotoxicol Environ Saf. 233: 113304. PMID: 35158256
- Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos. | Gao, M., et al. 2022. Int J Mol Sci. 23: PMID: 35563172
- Recent evidence for toxic effects of NH3 exposure on lung injury: Protective effects of L-selenomethionine. | Wang, A., et al. 2022. Ecotoxicol Environ Saf. 242: 113937. PMID: 35999759
- Intestinal barrier dysfunction induced by ammonia exposure in pigs in vivo and in vitro: The protective role of L-selenomethionine. | Zhang, X., et al. 2022. Ecotoxicol Environ Saf. 248: 114325. PMID: 36436255
- Selenium Speciation Analysis Reveals Improved Antioxidant Status in Finisher Pigs Fed L-Selenomethionine, Alone or Combined with Sodium Selenite, and Vitamin E. | Reinoso-Maset, E., et al. 2022. Biol Trace Elem Res.. PMID: 36577830
- L-selenomethionine affects liver development and glucolipid metabolism by inhibiting autophagy in zebrafish embryos. | Zhu, Y., et al. 2023. Ecotoxicol Environ Saf. 252: 114589. PMID: 36724712
Inhibitor of:
βA1/3-crystallin, βB3-crystallin, MTR, PRODH, PSTK, selenocysteine lyase, and SPCA2.Activator of:
BC100530, CHIC2, DPEP1, FANCL, GPx-6, Grx2, KSP37, Ly-49F, MP19, MPST, MsrA, R2, SELB, SELENBP1, SELENBP2, Selenium, selenocysteine lyase, Selenoprotein I, Selenoprotein K, Selenoprotein M marker, Selenoprotein N, Selenoprotein O, Selenoprotein W, SEP15, SEPHS1, TBG, TRH-DE, and TXNDC4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Selenomethionine, 250 mg | sc-204050 | 250 mg | $219.00 | |||
L-Selenomethionine, 1 g | sc-204050A | 1 g | $585.00 |